In-vitro antibacterial, antifungal and cytotoxic activity of cobalt (II), copper (II), nickel (II) and zinc (II) complexes with furanylmethyl- and thienylmethyl-dithiolenes: [1, 3-dithiole-2-one and 1,3-dithiole-2-thione]
In-vitro antibacterial, antifungal and cytotoxic activity of cobalt (II), copper (II), nickel (II) and zinc (II) complexes with furanylmethyl- and thienylmethyl-dithiolenes: [1, 3-dithiole-2-one and 1,3-dithiole-2-thione]
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DOI：
10.1080/14756360600810308
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发表时间：
2006-12-01
影响因子：
5.6
通讯作者：
Supuran, Claudiu T.
中科院分区：
文献类型：
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作者：
Chohan, Zahid H.;Shaikh, Ali U.;Supuran, Claudiu T.
合成了抗菌、抗真菌的呋喃甲基二硫烯及其钴(II)、铜(II)、镍(II)、锌(II)配合物，并对4种革兰氏阴性菌：大肠埃希菌、铜绿假单胞菌、伤寒沙门氏菌、福氏志贺氏菌和2株革兰氏阳性菌、枯草杆菌和金黄色葡萄球菌进行了体外抗菌活性的表征和筛选，并测定了它们的体外抗真菌活性。所有化合物均具有显著的抗菌和抗真菌活性。然而，与简单配体相比，金属配合物具有更好的活性。此外，还进行了卤水对虾的生物实验，以研究它们的体外细胞毒活性。
Some antibacterial and antifungal furanylmethyl- and thienylmethyl dithiolenes and, their Co(II), Cu(II), Ni (II) and Zn (II) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against four Gram-negative; Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Shigella flexeneri, and two Gram-positive; Bacillus subtilis and Staphylococcus aureus bacterial strains, and for in-vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. All compounds showed significant antibacterial and antifungal activity. The metal complexes, however, were shown to possess better activity as compared to the simple ligands. The brine shrimp bioassay was also carried out to study their in-vitro cytotoxic properties.