Point-of-care testing on admission to the intensive care unit: lactate and glucose independently predict mortality
Point-of-care testing on admission to the intensive care unit: lactate and glucose independently predict mortality
复制标题
DOI：
10.1515/cclm-2012-0258
复制
发表时间：
2013-02-01
影响因子：
6.8
通讯作者：
Luppa, Peter B.
中科院分区：
文献类型：
--
作者：
Martin, Jan;Blobner, Manfred;Luppa, Peter B.
背景资料：本研究的目的是回顾性调查是否参数的常规床旁检测（POCT）预测医院死亡率的危重外科患者入院重症监护室（ICU）。方法：动脉血分析1551例患者入院成人外科ICU的技术大学慕尼黑进行了审查。在血气分析仪上进行POCT。评估酸碱平衡状态与死亡率之间的关系。代谢性酸中毒定义为碱过量（BE）50% BE，阴离子间隙（AG）酸中毒定义为AG >16 mmol/L，高氯血症酸中毒定义为氯化物>115 mmol/L。代谢紊乱定义为BE ≥ 3 mmol/L。Logistic回归分析确定了与死亡率独立相关的变量。结果：总死亡率为8.8%。男性患者的死亡率更高（p=0.012）。非存活者的平均年龄更大（p55 mm Hg）（死亡率23.1%）。377例患者出现酸中毒（死亡率11.4%），其中163例患者出现乳酸酸中毒（死亡率19%）。死亡率（174例患者）为12.1%。死亡者的平均血糖水平高于存活者（p
Background: The aim of the study was to retrospectively investigate whether parameters of routine point-of-care testing (POCT) predict hospital mortality in critically ill surgical patients on admission to the intensive care unit (ICU).Methods: Arterial blood analyses of 1551 patients on admission to the adult surgical ICU of the Technical University Munich were reviewed. POCT was performed on a blood gas analyser. The association between acid-base status and mortality was evaluated. Metabolic acidosis was defined by base excess (BE) 50% of BE, anion gap (AG)-acidosis by AG >16 mmol/L, hyperchloraemic acidosis by chloride >115 mmol/L. Metabolic alkalosis was defined by BE >= 3 mmol/L. Logistic regression analysis identified variables independently associated with mortality.Results: Overall mortality was 8.8%. Mortality was greater in male patients (p=0.012). Mean age was greater in non-survivors (p55 mm Hg (mortality 23.1%). Three hundred and seventy-seven patients presented with acidosis (mortality 11.4%), thereof 163 patients with lactic acidosis (mortality 19%). Mortality for alkalosis (174 patients) was 12.1%. Mean blood glucose level for non-survivors was higher compared to survivors (p