Effectiveness of Using the Modified Checklist for Autism in Toddlers in Two-Stage Screening of Autism Spectrum Disorder at the 18-Month Health Check-Up in Japan
Effectiveness of Using the Modified Checklist for Autism in Toddlers in Two-Stage Screening of Autism Spectrum Disorder at the 18-Month Health Check-Up in Japan
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DOI：
10.1007/s10803-013-1864-1
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发表时间：
2014-01-01
影响因子：
3.9
通讯作者：
Kuroda, Miho
中科院分区：
文献类型：
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作者：
Kamio, Yoko;Inada, Naoko;Kuroda, Miho
为了确定修改后的幼儿自闭症检查表(M-ChAT)与为期18个月的常规健康检查相结合，是否能识别出患有自闭症谱系障碍(ASD)的日本幼儿。使用M-Chat进行了两阶段筛查，1,851名儿童参加了体检。ASD的最终诊断是在3岁时确诊的。筛查确定了20/51名ASD儿童：12/20名真阳性是发育迟缓，而16/22名假阴性是高功能的。ASD儿童的敏感度为0.476，特异度为0.986，阳性预测值为0.455，似然比为33.4.经过一些修改，M-Chat筛查成功地检测出患有和没有发育迟缓的自闭症幼儿，是一种很有前途的筛查工具，可以补充现有的社区监测。
To determine whether the Modified Checklist for Autism in Toddlers (M-CHAT) in conjunction with the routine 18-month health check-up identifies Japanese toddlers with autism spectrum disorder (ASD). Two-stage screening using the M-CHAT was conducted with 1,851 children attending the check-up. Final ASD diagnosis was confirmed at age a parts per thousand yen3 years. Screening identified 20/51 children with ASD: 12/20 true positives were developmentally delayed, whereas 16/22 false negatives were high-functioning. Sensitivity was 0.476, specificity 0.986, positive predictive value 0.455, and likelihood ratio 33.4 for children with ASD. With a few modifications, M-CHAT screening successfully detected toddlers with ASD with and without developmental delay and is a promising screening tool to complement existing community surveillance.