Memory and learning in pediatric bipolar disorder
Memory and learning in pediatric bipolar disorder
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DOI：
10.1097/01.chi.0000156660.30953.91
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发表时间：
2005-05-01
影响因子：
13.3
通讯作者：
Leibenluft, E
中科院分区：
文献类型：
--
作者：
McClure, EB;Treland, JE;Leibenluft, E
目的：验证儿童双相情感障碍（PBPD）患者在记忆功能测量方面表现出相对于年龄、性别和智商相当的无诊断对照组的损害的假设。方法：作者对35名门诊PBPD患者和20名健康对照者进行了一系列的语言和视觉空间记忆测试，他们作为志愿者参加了这项研究。各组在年龄、性别或智商上没有差异。结果：与成年BPD患者的研究结果一致，PBPD患者在言语学习/记忆和延迟面部识别记忆方面的表现比对照组更差。记忆受损在合并PBPD/注意缺陷/多动障碍或急性情绪症状的患者中尤为明显。结论：这些发现表明，言语学习和记忆以及视觉空间记忆的某些方面的缺陷是窄表型PBPD患者的特征。然而，需要进一步的研究来阐明合并症的注意力缺陷/多动障碍和急性情绪状态在这些缺陷出现中的作用。鉴于成人BPD和窄型PBPD之间记忆功能障碍的明显连续性，旨在阐明这组缺陷的潜在神经机制的研究是有必要的。
Objective: To test the hypothesis that patients with pediatric bipolar disorder (PBPD) would demonstrate impairment relative to diagnosis-free controls of comparable age, gender, and IQ on measures of memory functioning. Method: The authors administered a battery of verbal and visuospatial memory tests to 35 outpatients with PBPD and 20 healthy controls who participated as volunteers in this study. Groups did not differ on age, gender, or IQ. Results: Consistent with findings in adults with BPD, patients with PBPD performed more poorly than controls on measures of verbal learning/memory and delayed facial recognition memory. Impaired memory was particularly evident in patients with comorbid PBPD/attention-deficit/hyperactivity disorder or acute mood symptoms. Conclusions: These findings suggest that deficits in verbal learning and memory, as well as some aspects of visuospatial memory, characterize patients with narrow phenotype PBPD. Further research is needed, however, to clarify the roles of comorbid attention-deficit/hyperactivity disorder and acute mood state in the emergence of these deficits. Given the apparent continuity in memory dysfunction between adult BPD and narrow phenotype PBPD, research aimed at elucidating underlying neural mechanisms for this set of deficits is warranted.