RELEASED FORM OF CNTF RECEPTOR-ALPHA COMPONENT AS A SOLUBLE MEDIATOR OF CNTF RESPONSES
RELEASED FORM OF CNTF RECEPTOR-ALPHA COMPONENT AS A SOLUBLE MEDIATOR OF CNTF RESPONSES
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DOI：
10.1126/science.7681218
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发表时间：
1993-03-19
期刊：
影响因子：
56.9
通讯作者：
YANCOPOULOS, GD
中科院分区：
文献类型：
--
作者：
DAVIS, S;ALDRICH, TH;YANCOPOULOS, GD
睫状神经营养因子（CNTF）受体的α组分不同于其他已知的生长因子受体，因为它通过糖基-磷脂酰肌醇键固定在细胞膜上。这种连接的一个可能功能是允许这种受体成分的调节释放。通常对CNTF没有反应的细胞系对CNTF和可溶形式的CNTF α受体成分的组合治疗有反应。这些发现不仅证明了CNTF受体α链是功能性CNTF受体复合物的必需组分，而且还揭示了它可以作为异二聚体配体的一部分以可溶性形式发挥作用。可溶性CNTF受体的潜在生理作用是通过其在脑脊液中的存在和在周围神经损伤时从骨骼肌中释放而提出的。
The alpha component of the receptor for ciliary neurotrophic factor (CNTF) differs from other known growth factor receptors in that it is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage. One possible function of this type of linkage is to allow for the regulated release of this receptor component. Cell lines not normally responsive to CNTF responded to treatment with a combination of CNTF and a soluble form of the CNTF alpha receptor component. These findings not only demonstrate that the CNTF receptor alpha chain is a required component of the functional CNTF receptor complex but also reveal that it can function in soluble form as part of a heterodimeric ligand. Potential physiological roles for the soluble CNTF receptor are suggested by its presence in cerebrospinal fluid and by its release from skeletal muscle in response to peripheral nerve injury.