Injectable biodegradable materials for orthopedic tissue engineering
Injectable biodegradable materials for orthopedic tissue engineering
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DOI：
10.1016/s0142-9612(00)00108-3
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发表时间：
2000-12-01
期刊：
影响因子：
14
通讯作者：
Mikos, AG
中科院分区：
文献类型：
--
作者：
Temenoff, JS;Mikos, AG
每年进行的大量骨科手术，包括许多关节镜下进行的手术，已经引起了人们对用于骨和软骨再生的可注射生物降解材料的极大兴趣。为这些应用开发了各种材料，包括陶瓷、天然衍生物质和合成聚合物。这些材料表现出整体的生物相容性和适当的机械性能，以及促进组织形成，从而提供了一个重要的一步，微创骨科手术，这篇综述提供了这些材料的基础上的机械性能，生物相容性和再生效率的比较。每种材料的优点和缺点进行了解释，并提供可注射生物降解系统的设计标准。(C)2000爱思唯尔科技有限公司版权所有。
The large number of orthopedic procedures performed each year, including many performed arthroscopically, have led to great interest in injectable biodegradable materials for regeneration of bone and cartilage. A variety of materials have been developed for these applications, including ceramics, naturally derived substances and synthetic polymers. These materials demonstrate overall biocompatibility and appropriate mechanical properties, as well as promote tissue formation, thus providing an important step towards minimally invasive orthopedic procedures, This review provides a comparison of these materials based on mechanical properties, biocompatibility and regeneration efficacy. Advantages and disadvantages of each material are explained and design criteria for injectable biodegradable systems are provided. (C) 2000 Elsevier Science Ltd. All rights reserved.