A miniature confocal Raman probe for endoscopic use
A miniature confocal Raman probe for endoscopic use
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DOI：
10.1088/0031-9155/54/23/003
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发表时间：
2009-12-07
影响因子：
3.5
通讯作者：
Stone, N.
中科院分区：
文献类型：
--
作者：
Day, J. C. C.;Bennett, R.;Stone, N.
拉曼光谱是研究人体生化变化的有力工具。我们描述了一种微型的共聚焦光纤探头，旨在适应标准医学内窥镜的仪器通道。对该探针进行了优化，用于研究食管恶性肿瘤的癌变过程。描述了该探头的光学设计和制造，包括用于制造硅主板和夹具的各向异性湿法蚀刻技术。给出了聚四氟乙烯参考样品的光谱示例。从切除的食管组织获得的光谱采集时间低至2秒，显示了各种病理的可识别的生化变化。
Raman spectroscopy is a powerful tool for studying biochemical changes in the human body. We describe a miniature, confocal fibre optic probe intended to fit within the instrument channel of a standard medical endoscope. This probe has been optimized for the study of the carcinogenesis process of oesophageal malignancy. The optical design and fabrication of this probe is described including the anisotropic wet etching technique used to make silicon motherboards and jigs. Example spectra of PTFE reference samples are shown. Spectra with acquisition times as low as 2 s from resected oesophageal tissue are presented showing identifiable biochemical changes from various pathologies.