Tobacco use during cannabis cessation: Use patterns and impact on abstinence in a National Drug Abuse Treatment Clinical Trials Network Check for study
Tobacco use during cannabis cessation: Use patterns and impact on abstinence in a National Drug Abuse Treatment Clinical Trials Network Check for study
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DOI：
10.1016/j.drugalcdep.2018.07.018
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发表时间：
2018-11-01
影响因子：
4.2
通讯作者：
Gray, Kevin M.
中科院分区：
文献类型：
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作者：
McClure, Erin A.;Baker, Nathaniel L.;Gray, Kevin M.
背景：大麻使用者也使用烟草是很常见的。虽然数据表明，烟草使用者更难实现大麻戒烟，但对临床试验数据集的二次分析可能会深入了解促成这种关系的调节变量以及大麻治疗期间烟草使用的变化。这些都是这个次要analysis.Methods的目的：母研究是一个多站点的N-乙酰半胱氨酸大麻依赖性试验进行的国家药物滥用治疗临床试验网络。参与者是符合大麻依赖标准的寻求治疗的成年人（18-50岁）（N = 302）。对于吸烟者（n = 117），通过时间轴随访评估烟草使用情况，通过Fagerstrom尼古丁依赖试验（FTND）评估尼古丁依赖。结果指标包括：1）在烟草使用的基础上的治疗分配，尼古丁依赖，并同时大麻减少/abstinence的变化，和2）尼古丁依赖和大麻abstinence.Results之间的独立关联：吸烟者占样本的39%（117/302），与FTND评分中位数为3.0（10分制）。在基线尼古丁依赖评分较低的患者中，与安慰剂组相比，活性治疗组的吸烟率降低。中度/高度尼古丁依赖者在积极治疗后吸烟率略有增加。尼古丁依赖并不影响cannabis successful.Conclusions：大麻治疗期间吸烟受到影响，但依赖于基线尼古丁依赖的严重程度，虽然依赖水平并不影响大麻戒断。特别是由于大麻使用日益普遍，需要采取既处理烟草问题又处理大麻问题的干预措施。
Background: It is common for cannabis users to also use tobacco. While data suggest that tobacco users have more difficulty achieving cannabis cessation, secondary analyses of clinical trial data sets may provide insight into the moderating variables contributing to this relationship, as well as changes in tobacco use during cannabis treatment. Those were the aims of this secondary analysis.Methods: The parent study was a multi-site trial of N-acetylcysteine for cannabis dependence conducted within the National Drug Abuse Treatment Clinical Trials Network. Participants were treatment-seeking adults (ages 18-50) who met criteria for cannabis dependence (N = 302). For cigarette smokers (n = 117), tobacco use was assessed via timeline follow-back and nicotine dependence was assessed via the Fagerstrom Test for Nicotine Dependence (FTND). Outcome measures included: 1) changes in tobacco use based on treatment assignment, nicotine dependence, and concurrent cannabis reduction/abstinence, and 2) independent associations between nicotine dependence and cannabis abstinence.Results: Cigarette smokers accounted for 39% of the sample (117/302), with a median FTND score of 3.0 (10-point scale). Among those with lower baseline nicotine dependence scores, cigarette smoking was reduced in the active treatment group compared to placebo. Those with moderate/high levels of nicotine dependence showed slight increases in smoking following active treatment. Nicotine dependence did not affect cannabis cessation.Conclusions: Cigarette smoking during cannabis treatment was affected, but depended on baseline nicotine dependence severity, though dependence levels did not impact cannabis abstinence. Interventions that address both tobacco and cannabis are needed, especially due to an increasing prevalence of cannabis use.