Bone and Muscle Pleiotropy: The Genetics of Associated Traits.
Bone and Muscle Pleiotropy: The Genetics of Associated Traits.
复制标题
DOI：
10.1007/s12018-014-9159-4
复制
发表时间：
2014-06-01
影响因子：
1.8
通讯作者：
Blank RD
中科院分区：
文献类型：
--
作者：
Blank RD
骨骼和肌肉质量高度相关。在一定程度上，这是两个组织共享共同基因决定因素的结果。此外，这两种组织对它们的机械环境都有反应。小鼠的新遗传工具将允许感兴趣的基因在实验定义的环境中失活，从而使研究人员能够区分对每个组织的直接影响和对另一个组织的主要表型的生理反应。
Bone and muscle mass are highly correlated. In part, this is a consequence of both tissues sharing common genetic determinants. In addition, both tissues are responsive to their mechanical environments. New genetic tools in mice will allow genes of interest to be inactivated in experimentally defined contexts, thus allowing investigators to distinguish direct effects on each tissue from physiological responses to a primary phenotype in the other.