An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes
An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes
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DOI：
10.1093/ajcn/78.4.734
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发表时间：
2003-10-01
影响因子：
7.1
通讯作者：
Hoover, H
中科院分区：
文献类型：
--
作者：
Gannon, MC;Nuttall, FQ;Hoover, H
背景：在单餐研究中，饮食蛋白质不会导致患有或不患有2型糖尿病的人的葡萄糖浓度增加，即使由此产生的氨基酸可以用于糖异生。目的：比较高蛋白饮食和目前几个科学组织推荐的典型健康(对照)饮食的代谢影响。设计：对12名未经治疗的2型糖尿病患者分别食用5wk的饮食(以2-5wk的洗涤期分隔)，研究这两种饮食的代谢影响。高蛋白饲料中蛋白质、碳水化合物、脂肪的比例为30：40：30，对照组为15：55：30。结果：以空腹血糖浓度为基线来确定曲线下面积，高蛋白饮食导致平均24小时积分葡萄糖面积反应减少40%。高蛋白饲料和对照饲料5wk后糖化血红蛋白分别降低0.8%和0.3%，差异显著(P<；0.05)。随着时间的推移，高蛋白饮食后的变化速度也显著大于对照饮食后(P<；0.001)。高蛋白饮食后空腹三酰甘油显著低于对照饮食后。两种饮食后胰岛素、C肽和游离脂肪酸浓度没有显著差异。结论：高蛋白饮食可降低2型糖尿病患者餐后7天的血糖，并改善整体血糖控制。然而，有必要进行更长期的研究，以确定总的反应幅度、可能的不良反应以及饮食的长期可接受性。
Background: In single-meal studies, dietary protein does not result in an increase in glucose concentrations in persons with or without type 2 diabetes, even though the resulting amino acids can be used for gluconeogenesis.Objective: The metabolic effects of a high-protein diet were compared with those of the prototypical healthy (control) diet, which is currently recommended by several scientific organizations.Design: The metabolic effects of both diets, consumed for 5 wk each (separated by a 2-5-wk washout period), were studied in 12 subjects with untreated type 2 diabetes. The ratio of protein to carbohydrate to fat was 30:40:30 in the high-protein diet and 15:55:30 in the control diet. The subjects remained weight-stable during the study.Results: With the fasting glucose concentration used as a baseline from which to determine the area under the curve, the high-protein diet resulted in a 40% decrease in the mean 24-h integrated glucose area response. Glycated hemoglobin decreased 0.8% and 0.3% after 5 wk of the high-protein and control diets, respectively; the difference was significant (P < 0.05). The rate of change over time was also significantly greater after the high-protein diet than after the control diet (P < 0.001). Fasting triacylglycerol was significantly lower after the high-protein diet than after the control diet. Insulin, C-peptide, and free fatty acid concentrations were not significantly different after the 2 diets.Conclusion: A high-protein diet lowers blood glucose postpran-7 dially in persons with type 2 diabetes and improves overall glucose control. However, longer-term studies are necessary to determine the total magnitude of response, possible adverse effects, and the long-term acceptability of the diet.