The Features of the Synovium in Early Rheumatoid Arthritis According to the 2010 ACR/EULAR Classification Criteria
The Features of the Synovium in Early Rheumatoid Arthritis According to the 2010 ACR/EULAR Classification Criteria
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DOI：
10.1371/journal.pone.0036668
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发表时间：
2012-05-04
期刊：
影响因子：
3.7
通讯作者：
Tak, Paul P.
中科院分区：
文献类型：
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作者：
van de Sande, Marleen G. H.;de Hair, Maria J. H.;Tak, Paul P.
目的：在早期关节炎队列中已经表明，2010年ACR/EULAR类风湿性关节炎（RA）标准能够实现早期诊断，可能以患者人群更加异质为代价。我们描述了根据这些新标准分类的RA患者滑膜炎症的特征。方法：在基线时，滑膜组织活检样本来自疾病缓解抗风湿药物（DMARD）初治的早期RA患者（临床体征和症状
Objective: It has been shown in early arthritis cohorts that the 2010 ACR/EULAR criteria for rheumatoid arthritis (RA) enable an earlier diagnosis, perhaps at the cost of a somewhat more heterogeneous patient population. We describe the features of synovial inflammation in RA patients classified according to these new criteria.Methods: At baseline, synovial tissue biopsy samples were obtained from disease-modifying antirheumatic drug (DMARD)-naive early RA patients (clinical signs and symptoms