Sonodynamic therapy: Rapid progress and new opportunities for non-invasive tumor cell killing with sound.
Sonodynamic therapy: Rapid progress and new opportunities for non-invasive tumor cell killing with sound.
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DOI：
10.1016/j.canlet.2022.215592
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发表时间：
2022-04-28
期刊：
影响因子：
9.7
通讯作者：
Price RJ
中科院分区：
文献类型：
--
作者：
Nowak KM;Schwartz MR;Breza VR;Price RJ
实体瘤的治疗在很大程度上依赖于化疗、放射治疗、手术切除和/或免疫治疗。尽管多年来已经提出了许多替代的非侵入性实体肿瘤治疗方法，并继续在各种情况下进行测试，但对于当前的癌症医疗机构来说，根除肿瘤细胞仍然是一项艰巨的任务。事实上，实体肿瘤表现出物理和生化上的异质性微环境，使它们能够很容易地获得耐药机制。声动力疗法(SDT)是一种能够在控制肿瘤生长的同时限制非靶点效应和毒性的治疗方式，近年来进展加快。SDT结合了“声波增敏剂”和聚焦声能的非侵入性应用[即聚焦超声(FUS)]，以推动高度局部形成肿瘤细胞杀伤活性氧簇(ROS)。超声增敏剂选择性地积聚在肿瘤细胞中，之后融合辐射通过迫使肿瘤细胞死亡来消除肿瘤。在这篇文章中，我们全面回顾了最近应用SDT治疗原发和转移肿瘤的研究。我们讨论了声敏剂、与SDT的联合治疗、在确定SDT诱导的细胞毒性机制方面的进展，以及SDT作为抗肿瘤免疫调节剂的前景。
Solid tumor treatment relies heavily upon chemotherapies, radiation, surgical resection, and/or immunotherapies. Although many alternative non-invasive solid tumor therapies have been proposed through the years and continue to be tested in various contexts, tumor cell eradication remains a daunting task for the current cancer armamentarium. Indeed, solid tumors exhibit physically and biochemically heterogenous microenvironments, allowing them to easily acquire resistance mechanisms. Progress in sonodynamic therapy (SDT), a treatment modality capable of controlling tumor growth while limiting off-target effects and toxicities, has accelerated in recent years. SDT combines “sonosensitizing” agents with the non-invasive application of focused acoustic energy [i.e. focused ultrasound (FUS)] to drive highly localized formation of tumor cell-killing reactive oxygen species (ROS). Sonosensitizers selectively accumulate in tumor cells, after which FUS radiation eliminates the tumor by forcing the tumor cells to undergo cell death. In this article, we comprehensively review recent studies wherein SDT has been applied to treat primary and metastatic tumors. We discuss sonosensitizers, combination therapies with SDT, developments in defining the mechanism of SDT-induced cell cytotoxicity, and the promise SDT offers as a modulator of anti-tumor immunity.
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