INCREASED EXPRESSION OF ADHESION MOLECULES (ICAM-1 AND LFA-1) ON ALVEOLAR MACROPHAGES FROM ASTHMATIC-PATIENTS
INCREASED EXPRESSION OF ADHESION MOLECULES (ICAM-1 AND LFA-1) ON ALVEOLAR MACROPHAGES FROM ASTHMATIC-PATIENTS
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DOI：
10.1111/j.1398-9995.1993.tb00751.x
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发表时间：
1993-11-01
期刊：
影响因子：
12.4
通讯作者：
BOUSQUET, J
中科院分区：
文献类型：
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作者：
CHANEZ, P;VIGNOLA, AM;BOUSQUET, J
在哮喘中观察到的气道炎症中，活化的巨噬细胞以增加的数量存在。粘附分子是白细胞与内皮细胞或其他白细胞之间的细胞接触所必需的，并且它们由炎症刺激诱导。应用免疫细胞化学方法对11例正常人和13例哮喘患者肺泡巨噬细胞表面粘附分子ICAM-1和LFA-1的表达进行了研究。使用两种特异性单克隆抗体，并通过碱性磷酸酶-抗碱性磷酸酶（APAAP）方法显示反应。哮喘患者肺组织中ICAM-1和LFA-1阳性细胞百分率均显著高于正常对照组（P
In the airways inflammation observed in asthma, activated macrophages are present in increased numbers. Adhesion molecules are required for the cell:cell contacts between leukocytes and endothelial cells or other leukocytes, and they are induced by inflammatory stimuli. We studied the expression of two adhesion molecules (ICAM-1 and LFA-1) on alveolar macrophages recovered by bronchoalveolar lavage from 11 normal subjects and 13 asthmatic patients by using immunocytochemistry. Two specific monoclonal antibodies were used, and the reaction was revealed by the alkaline phosphatase-antialkaline phosphatase (APAAP) method. The percentage of cells expressing ICAM-1 or LFA-1 was significantly increased in asthmatic patients, as compared with normal subjects (P