A comparative analysis of NLRP3-related inflammatory mediators in synovial fluid in temporomandibular joint osteoarthritis and internal derangement.
A comparative analysis of NLRP3-related inflammatory mediators in synovial fluid in temporomandibular joint osteoarthritis and internal derangement.
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颞下颌关节骨关节炎与内紊乱滑液中NLRP3相关炎症介质的比较分析
DOI：
10.1186/s12891-021-04092-0
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发表时间：
2021-02-26
影响因子：
2.3
通讯作者：
Gong Z
中科院分区：
文献类型：
--
作者：
Jia M;Lv Y;Xu Y;Gong Z
核巧酸结合寡聚化结构域样受体pyrin domain containing 3（NLRP 3）炎性体信号通路是炎症领域的研究热点。然而，关于NLRP 3炎症体通路与颞下颌关节骨关节炎（TMJOA）的关系的研究很少。本研究的目的是检测髁突软骨退变患者滑液中与NLRP 3炎性体相关的炎症介质的表达，并验证透明质酸钠（HA）治疗TMJOA的临床效果。将诊断为无髁突缺损的颞下颌关节内紊乱病（TMJID）和有髁突缺损的TMJOA患者分为两组。每组各30例患者，通过酶联免疫吸附试验（ELISA）检测滑液中与NLRP 3炎性体相关的炎症介质，包括白细胞介素-1 β（IL-1β）、IL-18、NLRP 3和半胱氨酸天冬氨酸特异性蛋白酶1（CASP 1）。TMJOA组中的18例患者在两次HA治疗后重新测试，以评估HA的治疗效果。IL-1β、IL-18、NLRP 3和CASP 1在两组中均呈阳性表达，TMJOA伴髁突缺损组的表达高于TMJID组（P < 0.05）。两次HA治疗后，IL-1β、IL-18和NLRP 3均降低（P<0.05），但两次HA注射后CASP 1无显著差异（P = 0.549）。NLRP 3炎症体信号通路可能参与髁突退变。HA可减少部分炎症分子的表达，减轻炎症反应。在线版本包含补充材料，可通过10.1186/s12891-021-04092-0获得。
The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome signaling pathway is a highlighted topic in the field of inflammation. However, there is little research on the relationship between the NLRP3 inflammasome pathway and temporomandibular joint osteoarthritis (TMJOA). The aim of this study was to examine the expression of inflammatory mediators related to the NLRP3 inflammasome in the synovial fluid of patients with condylar cartilage degeneration and verify the clinical effects of sodium hyaluronic acid (HA) treatment on TMJOA. Patients diagnosed with temporomandibular joint internal derangement (TMJID) without condylar defects and TMJOA with condylar defects were divided into two groups. There were thirty patients in each group, and inflammatory mediators related to the NLRP3 inflammasome, including interleukin-1 beta (IL-1β), IL-18, NLRP3, and cysteinyl aspartate specific proteinase 1 (CASP1), in synovial fluid were measured by enzyme-linked immunosorbent assay (ELISA). Eighteen patients in the TMJOA group were retested after two HA treatments to evaluate the therapeutic effects of HA. IL-1β, IL-18, NLRP3 and CASP1 were all positive in the two groups, and TMJOA patients with condylar defects had higher expression of these molecules than TMJID patients (P < 0.05). IL-1β, IL-18, and NLRP3 were decreased after two HA treatments (P<0.05), but there was no significant difference in CASP1 after two HA injections (P = 0.549). The NLRP3 inflammasome signaling pathway may be involved in condylar degeneration. HA could reduce some inflammatory molecules to alleviate inflammation. The online version contains supplementary material available at 10.1186/s12891-021-04092-0.
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影响因子：
27.4
作者：
Huesa C;Ortiz AC;Dunning L;McGavin L;Bennett L;McIntosh K;Crilly A;Kurowska-Stolarska M;Plevin R;van 't Hof RJ;Rowan AD;McInnes IB;Goodyear CS;Lockhart JC;Ferrell WR
通讯作者：
Ferrell WR
DOI：
10.6061/clinics/2012(01)06
发表时间：
2012
期刊：
Clinics (Sao Paulo, Brazil)
影响因子：
--
作者：
Sartori-Cintra AR;Mara CS;Argolo DL;Coimbra IB
通讯作者：
Coimbra IB
影响因子：
2.2
作者：
Verner, Francielle Silvestre;Portella Guedes Visconti, Maria Augusta;Devito, Karina Lopes
通讯作者：
Devito, Karina Lopes
影响因子：
3.4
作者：
Zhao, Ling-Rui;Xing, Run-Lin;Zhang, Li
通讯作者：
Zhang, Li
TNF 加速生物力学刺激诱发颞下颌关节病大鼠下颌髁软骨细胞的死亡
影响因子：
3.7
作者：
Yang H;Zhang M;Wang X;Zhang H;Zhang J;Jing L;Liao L;Wang M
通讯作者：
Wang M