Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT.
Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT.
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DOI：
10.1155/2011/817250
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发表时间：
2011
影响因子：
7.6
通讯作者：
Rylander CG
中科院分区：
文献类型：
--
作者：
Gurjarpadhye AA;Vogt WC;Liu Y;Rylander CG
皮肤高度无序的折射率分布导致入射光的多次散射，限制了光学成像和治疗深度。我们假设局部机械压缩通过从真皮胶原基质中排出非结合水，增加蛋白质浓度和减少组织成分之间指数不匹配界面的数量来减少散射。扫描源光学相干断层扫描（OCT）系统用于评估离体猪皮肤厚度和群折射率的变化，以及在体人皮肤成像时信号强度谱的变化。对离体猪皮进行压缩，有效应变为- 58.5%，折射率从1.39增加到1.50，水体积分数从0.66减少到0.20。体内OCT信号强度在1mm深度增加1.5 dB，可能是由于水从压缩区域转移。这些发现表明，局部压缩可用于增强基于光的诊断和治疗技术。
The highly disordered refractive index distribution in skin causes multiple scattering of incident light and limits optical imaging and therapeutic depth. We hypothesize that localized mechanical compression reduces scattering by expulsing unbound water from the dermal collagen matrix, increasing protein concentration and decreasing the number of index mismatch interfaces between tissue constituents. A swept-source optical coherence tomography (OCT) system was used to assess changes in thickness and group refractive index in ex vivo porcine skin, as well as changes in signal intensity profile when imaging in vivo human skin. Compression of ex vivo porcine skin resulted in an effective strain of −58.5%, an increase in refractive index from 1.39 to 1.50, and a decrease in water volume fraction from 0.66 to 0.20. In vivo OCT signal intensity increased by 1.5 dB at a depth of 1 mm, possibly due to transport of water away from the compressed regions. These finding suggest that local compression could be used to enhance light-based diagnostic and therapeutic techniques.