Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion
Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion
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DOI：
10.3892/etm.2011.319
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发表时间：
2011-11-01
影响因子：
2.7
通讯作者：
Andoh, Akira
中科院分区：
文献类型：
--
作者：
Mochizuki, Yosuke;Saito, Yasuharu;Andoh, Akira
内镜下黏膜下剥离术（ESD）联合后续放化疗（CRT）治疗浅表性食管鳞状细胞癌（浅表性ESCC）的疗效、安全性和临床结果仍不明确。我们评估了ESD联合CRT治疗浅表性ESCC的效果。2004年至2010年，14例侵犯黏膜肌层或黏膜下层的浅表性ESCC患者接受了ESD联合CRT治疗。所有患者均成功进行了病灶的整块切除。病灶平均直径为25毫米（范围10 - 55毫米）。肿瘤浸润深度分布为：8例患者浸润至黏膜肌层，4例患者浸润至黏膜下层上1/3（sm1），2例患者浸润至黏膜下层中1/3（sm2）。所有患者的侧切缘和血管浸润均无癌细胞，但2例患者检测到淋巴结受累。CRT后的平均随访期为45个月（范围19 - 70个月）。无患者死于食管癌。所有患者均未观察到食管癌的复发或转移。ESD联合CRT对浅表性ESCC是有效的。
The efficacy, safety and clinical outcomes of a combination of endoscopic submucosal dissection (ESD) with subsequent chemoradiation therapy (CRT) for superficial esophageal squamous cell carcinomas (superficial ESCC) remain unclear. We assessed the outcome of the combination of ESD plus CRT for superficial ESCC. Fourteen patients with superficial ESCC invading into the muscularis mucosa or submucosa were treated with ESD plus CRT from 2004 to 2010. En bloc resection of the lesion was successfully performed in all patients. The mean diameter of the lesions was 25 mm (range 10-55). The distribution of the depth of tumor invasion was to the muscularis mucosa in 8 patients, to the upper submucosal third (sm1) in 4 patients and to the middle submucosal third (sm2) in 2 patients. The laterally resected margins and vascular invasion were cancer-negative in all patients, but lymph node involvement was detected in 2 patients. The mean follow-up period after CRT was 45 months (range 19-70). No patients died of esophageal cancer. Recurrence or metastasis of the esophageal cancer was not observed in any of the patients. The combination of ESD plus CRT is effective for superficial ESCC.