Serum PFAS and Urinary Phthalate Biomarker Concentrations and Bone Mineral Density in 12-19 Year Olds: 2011-2016 NHANES
Serum PFAS and Urinary Phthalate Biomarker Concentrations and Bone Mineral Density in 12-19 Year Olds: 2011-2016 NHANES
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DOI：
10.1210/clinem/dgac228
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发表时间：
2022-05-10
影响因子：
5.8
通讯作者：
Fleisch, Abby F.
中科院分区：
文献类型：
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作者：
Carwile, Jenny L.;Seshasayee, Shravanthi M.;Fleisch, Abby F.
背景全氟烷基和多氟烷基物质（PFAS）和邻苯二甲酸盐是两类环境内分泌干扰物，可能与区域性骨密度降低（aBMD）有关。目的探讨青少年血清PFAS和尿邻苯二甲酸酯生物标志物浓度及其混合物与aBMD Z评分之间的关系。设计、患者和测量我们检查了2011年至2016年国家健康和营养检查调查中12至19岁男性（n = 453）和女性（n = 395）参与者的连续横断面数据，测量了血清PFAS、尿邻苯二甲酸酯代谢物和双能X线吸收法aBMD Z评分（全身减去头部）。在性别特异性模型中，我们使用线性回归来检查个体PFAS和邻苯二甲酸酯生物标志物与aBMD Z分数的相关性，并使用贝叶斯核机器回归来检查总体PFAS/邻苯二甲酸酯生物标志物混合物与aBMD Z分数的相关性。我们重复了分析，并按种族/民族进行分层。结果参与者的年龄（平均值+/- SD）为15 +/- 2.1岁。在男性中，血清全氟辛酸盐（PFOA）、全氟辛烷磺酸盐、尿邻苯二甲酸单异丁酯（MiBP）、邻苯二甲酸单正丁酯和总体PFAS/邻苯二甲酸酯混合物每增加一倍，aBMD Z评分就降低（例如，PFOA：-0.24; 95% CI，-0.41至-0.06）。血清PFOA和尿MiBP与女性较高的aBMD Z评分相关（例如，PFOA：0.09; 95% CI，-0.07至0.25）。结果不因种族/民族而有所不同。结论某些PFAS和邻苯二甲酸酯可能与青少年男性骨密度降低有关。骨矿物质密度在整个生命过程中跟踪，因此如果在纵向队列中复制，这一发现可能对终身骨骼健康有影响。
Context Per- and polyfluoroalkyl substances (PFAS) and phthalates are 2 families of environmental endocrine disruptors that may be associated with areal lower bone mineral density (aBMD). Objective To examine associations between serum PFAS and urinary phthalate biomarker concentrations and their mixtures with aBMD Z-scores in adolescents. Design, Patients, and Measures We examined serial cross-sectional data from male (n = 453) and female (n = 395) 12- to 19-year-old participants in the 2011 through 2016 National Health and Nutrition Examination Survey with measures of serum PFAS, urinary phthalate metabolites, and dual-energy X-ray absorptiometry aBMD Z-scores (total body less head). In sex-specific models, we used linear regression to examine associations of individual PFAS and phthalate biomarkers with aBMD Z-scores, and Bayesian kernel machine regression to examine the association of the overall PFAS/phthalate biomarker mixture with aBMD Z-scores. We replicated the analysis, stratifying by race/ethnicity. Results Participants were (mean +/- SD) 15 +/- 2.1 years of age. In males, each doubling of serum perfluorooctanoate (PFOA), perfluorooctane sulfonate, urinary mono-isobutyl phthalate (MiBP), mono-n-butyl phthalate, and the overall PFAS/phthalate mixture was associated with a lower aBMD Z-score (eg, for PFOA: -0.24; 95% CI, -0.41 to -0.06). Serum PFOA and urinary MiBP were associated with higher aBMD Z-scores in females (eg, for PFOA: 0.09; 95% CI, -0.07 to 0.25). Findings did not differ by race/ethnicity. Conclusions Certain PFAS and phthalates may be associated with reduced bone mineral density in adolescent males. Bone mineral density tracks across the life course, so if replicated in longitudinal cohorts, this finding may have implications for lifelong skeletal health.