POTENTIATED NECROSIS OF CULTURED CORTICAL-NEURONS BY NEUROTROPHINS
POTENTIATED NECROSIS OF CULTURED CORTICAL-NEURONS BY NEUROTROPHINS
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DOI：
10.1126/science.7725105
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发表时间：
1995-04-28
期刊：
影响因子：
56.9
通讯作者：
CHOI, DW
中科院分区：
文献类型：
--
作者：
KOH, JY;GWAG, BJ;CHOI, DW
神经营养素对几种形式的神经元变性在小鼠皮层细胞培养的影响进行了检查。与其他研究一致，脑源性神经营养因子、神经营养因子-3和神经营养因子-4/5都减弱了由血清剥夺或暴露于钙通道拮抗剂尼莫地平诱导的凋亡性死亡。然而，出乎意料的是，用这些相同的神经营养因子预处理24小时显著增强了由暴露于氧-葡萄糖剥夺或N-甲基-D-天冬氨酸诱导的坏死性死亡。因此，某些神经营养因子可能对相同神经元中不同类型的死亡具有相反的作用。
The effects of neurotrophins on several forms of neuronal degeneration in murine cortical cell cultures were examined. Consistent with other studies, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 all attenuated the apoptotic death induced by serum deprivation or exposure lo the calcium channel antagonist nimodipine, Unexpectedly, however, 24-hour pretreatment with these same neurotrophins markedly potentiated the necrotic death induced by exposure to oxygen-glucose deprivation or N-methyl-D-aspartate. Thus, certain neurotrophins may have opposing effects on different types of death in the same neurons.