EFFECTS OF GLUCOSE, INSULIN AND GLUCAGON ON AMYLASE SECRETION FROM INCUBATED MOUSE PANCREAS
EFFECTS OF GLUCOSE, INSULIN AND GLUCAGON ON AMYLASE SECRETION FROM INCUBATED MOUSE PANCREAS
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DOI：
10.1007/bf00589222
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发表时间：
1974-01-01
影响因子：
4.5
通讯作者：
DANIELSSON, A
中科院分区：
文献类型：
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作者：
DANIELSSON, A
葡萄糖抑制淀粉酶释放从分批培养和灌流件的小鼠胰腺。胰岛素（100μg/ml）可抑制淀粉酶分泌。然而，这些影响似乎是相互独立的，因为二氮嗪，葡萄糖诱导的胰岛素释放的有效抑制剂，并没有消除葡萄糖对淀粉酶分泌的影响。胰高血糖素（10-100 μg/ml）对培养胰腺淀粉酶的释放无影响。胰高血糖素以前已被证明在体内抑制外分泌。目前的结果表明，胰高血糖素的抑制作用可能是通过增加血清葡萄糖水平和随后的胰岛素释放介导的。
Glucose inhibited amylase release from batch-incubated and perifused pieces of mouse pancreas. Insulin (100μg/ml) reduced the amylase secretion. These effects, however, seemed to be independent of each other, since diazoxide, a potent inhibitor of glucose-induced insulin release, did not abolish the effect of glucose on amylase secretion. Glucagon (10–100 μg/ml) had no effect on the release of amylase from incubated pancreas. Glucagon has previously been shown to inhibit exocrine secretionin vivo. The present results suggest that the inhibitory action of glucagon may be mediated via an increased level of serum glucose and the subsequent release of insulin.