Highly Purified Eicosapentaenoic Acid May Increase Low-Density Lipoprotein Particle Size by Improving Triglyceride Metabolism in Patients With Hypertriglyceridemia
Highly Purified Eicosapentaenoic Acid May Increase Low-Density Lipoprotein Particle Size by Improving Triglyceride Metabolism in Patients With Hypertriglyceridemia
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DOI：
10.1253/circj.cj-12-1401
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发表时间：
2013-09-01
影响因子：
3.3
通讯作者：
Hirayama, Atsushi
中科院分区：
文献类型：
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作者：
Tani, Shigemasa;Nagao, Ken;Hirayama, Atsushi
背景：本研究的目的是评估高纯度二十碳五烯酸 (EPA) 在增加低密度脂蛋白 (LDL) 粒径方面的作用，这是摄入 EPA 预防冠状动脉事件的可能机制之一。 方法和结果：高甘油三酯血症受试者被随机分配到对照组 (n=72) 或 EPA 组 (n=72；EPA) 方案 1,800 mg/天，持续 6 个月）。在 EPA 组中，血清 LDL 胆固醇和高密度脂蛋白胆固醇水平保持不变，但根据脂蛋白聚丙烯酰胺凝胶电泳测量的 LDL 相对迁移率，LDL 粒径显着增加，血清富含甘油三酯的脂蛋白 (TRL) 水平显着降低。在对照组中没有观察到这些变化。调整冠状动脉危险因素后，多变量逻辑回归分析确定血清 EPA 相关标志物（6 个月 EPA、6 个月 EPA/花生四烯酸 [AA] 比率、Δ EPA 变化和 Δ EPA/AA）升高，以及他汀类药物和 EPA 治疗作为与 LDL 粒径增加相关的自变量。 Delta TRL 与 Delta LDL 粒径呈负相关，表明甘油三酯代谢的改善与 LDL 粒径的增加相关。结论：EPA 通过改善甘油三酯代谢来增加 LDL 粒径； EPA 治疗后的血清 EPA 水平和 EPA/AA 比值可能是 LDL 颗粒大小增加的有用标志。
Background: The purpose of this study was to evaluate the effect of highly purified eicosapentaenoic acid (EPA) in increasing low-density lipoprotein (LDL) particle size, as one of the possible mechanisms by which intake of EPA may prevent coronary events.Methods and Results: Hypertriglyceridemic subjects were randomly assigned to a control group (n=72) or an EPA group (n=72; EPA regimen 1,800 mg/day for 6 months). In the EPA group, the serum LDL-cholesterol and high-density lipoprotein cholesterol levels remained unchanged, but there was a significant increase in LDL particle size based on LDL-relative mobility measured on lipoprotein polyacrylamide-gel electrophoresis, and a significant decrease in serum triglyceride-rich lipoproteins (TRLs) level. None of these changes were observed in the control group. After adjustments for coronary risk factors, multivariate logistic regression analysis identified elevation of serum EPA-related markers (6-month EPA, 6-month EPA/arachidonic acid [AA] ratio, change in [Delta] EPA, and Delta EPA/AA), and treatment with statins and EPA as independent variables associated with increase in LDL particle size. Negative correlations were found between Delta TRLs and Delta LDL particle size, suggesting that improvement in triglyceride metabolism was associated with an increase in LDL particle size.Conclusions: EPA increases LDL particle size by improving triglyceride metabolism; and serum EPA level and EPA/AA ratio after EPA treatment may be useful markers of increased LDL particle size.