Regulatory B cells in autoimmune diseases and mucosal immune homeostasis.
Regulatory B cells in autoimmune diseases and mucosal immune homeostasis.
复制标题
DOI：
10.3109/08916931003782189
复制
发表时间：
2011-02
期刊：
影响因子：
3.5
通讯作者：
Wei B
中科院分区：
文献类型：
--
作者：
Li X;Braun J;Wei B
B淋巴细胞通过次级淋巴器官的器官发生、向T细胞呈递抗原、产生抗体和分泌细胞因子来促进生理免疫。它们在几种自身免疫性疾病中的作用也是众所周知的，主要是作为致病性抗体的产生者。然而，B细胞的某些亚群正在成为小鼠和人类中重要的调节细胞群。B细胞的调节功能已在多种自身免疫性疾病的小鼠模型中得到证实，所述自身免疫性疾病包括胶原诱导的关节炎（CIA）、实验性自身免疫性脑脊髓炎（EAE）、前房相关免疫偏离（ACAID）、糖尿病、接触性超敏反应（CHS）和肠粘膜炎症。从小鼠和人类研究中积累的证据证实了调节性B细胞的存在，并开始确定其作用机制。本文首先回顾了自身免疫性疾病中具有调节功能的B细胞的历史，并总结了目前对这类B细胞亚群特征的认识。然后，我们讨论了可能的调节机制的B细胞，并具体定义的作用，调节B细胞在肠道免疫稳态。
B lymphocytes contribute to physiological immunity through organogenesis of secondary lymphoid organs, presentation of antigen to T cells, production of antibodies, and secretion of cytokines. Their role in several autoimmune diseases, mainly as producers of pathogenic antibodies, is also well known. However, certain subsets of B cells are emerging as the important regulatory cell populations in both mouse and human. The regulatory functions of B cells have been demonstrated in a variety of mouse models of autoimmune diseases including collagen-induced arthritis (CIA), experiment autoimmune encephalomyelitis (EAE), anterior chamber-associated immune deviation (ACAID), diabetes, contact hypersensitivity (CHS), and intestinal mucosal inflammation. Accumulating evidence from both mouse and human studies confirms the existence of regulatory B cells, and is beginning to define their mechanisms of action. In this article, we first review the history of B cells with regulatory function in autoimmune diseases, and summarize the current understanding about the characterizations of such B-cell subsets. We then discuss the possible regulatory mechanisms of B cells, and specifically define the role of regulatory B cells in immune homeostasis in the intestine.
登录
查看更多内容
影响因子：
4.4
作者：
Evans, Jamie G.;Chavez-Rueda, Karina A.;Mauri, Claudia
通讯作者：
Mauri, Claudia
影响因子：
5.4
作者：
Deshpande, SP;Zheng, M;Rouse, BT
通讯作者：
Rouse, BT
DOI：
10.1056/nejmoa0706383
发表时间：
2008-02-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hauser, Stephen L;Waubant, Emmanuelle;Smith, Craig H
通讯作者：
Smith, Craig H
影响因子：
4.4
作者：
Hussain, Shabbir;Delovitch, Terry L.
通讯作者：
Delovitch, Terry L.
影响因子：
15.9
作者：
DesaiMehta, A;Lu, LJ;Datta, SK
通讯作者：
Datta, SK