Cortical thickness in primary sensorimotor cortex influences the effectiveness of paired associative stimulation
Cortical thickness in primary sensorimotor cortex influences the effectiveness of paired associative stimulation
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DOI：
10.1016/j.neuroimage.2012.01.052
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发表时间：
2012-04-02
期刊：
影响因子：
5.7
通讯作者：
Ragert, Patrick
中科院分区：
文献类型：
--
作者：
Conde, Virginia;Vollmann, Henning;Ragert, Patrick
一般说来，非侵入性脑刺激方案和配对联想刺激(PAS)似乎改变了皮质脊髓的兴奋性，从而影响了受试者之间高度可变性的行为。这种差异的原因是多维的，在某种程度上仍然未知。在这里，我们测试了这样的假设，即皮质厚度的个体差异可以解释PAS诱导的兴奋性变化的一些变异性。易化性PAS方案(PAS(LTP))10分钟后，大多数受试者(14/19名受试者)的皮质脊髓兴奋性迅速增加，而其他受试者(5/19名受试者)则没有这种效果。基于高分辨率T1加权图像的全脑相关分析显示，PAS(LTP)诱导的兴奋性变化仅与左侧感觉运动皮质(SM1)的皮质厚度呈显著正相关。在其他潜在的影响因素中，仅皮质厚度一项就解释了PAS(LTP)差异的大约一半，这表明后遗症较强的受试者是该区域灰质较厚的人。基于这些发现，我们提供了新的证据，证明局部大脑结构影响PAS(LTP)诱导的个体功能可塑性。尽管这种效应的潜在神经生理学和/或解剖学原因目前仍不清楚，但我们得出结论，在使用非侵入性脑刺激技术的研究中，皮质厚度应该被视为一个重要的且到目前为止尚未被认识到的调节因素。(C)2012 Elsevier Inc.保留所有权利。
Non-invasive brain stimulation protocols in general and paired associative stimulation (PAS) in particular seem to alter corticospinal excitability and thereby to influence behaviour with a high degree of inter-subject variability. The cause of this variability is multidimensional and to some extent still unknown. Here, we tested the hypothesis that individual variations in cortical thickness can explain some of the variability of PAS-induced excitability changes. Ten minutes of a facilitatory PAS protocol (PAS(LTP)) rapidly increased corticospinal excitability in the majority of the subjects (14/19 subjects) while others showed no such effect (5/19 subjects). A whole brain correlation analysis based on high resolution T1-weighted images revealed a significant positive relationship of PAS(LTP)-induced excitability changes with cortical thickness of the underlying left sensorimotor cortex (SM1) only. Cortical thickness alone, among other potential influencing factors, explained about half of the PAS(LTP) variance, indicating that subjects with a strong after-effect were those with thicker gray matter in this region. Based on these findings, we provide novel evidence that local brain structure influences the individual amount of functional plasticity induced by PAS(LTP). While the underlying neurophysiological and/or anatomical reasons for this effect still remain elusive at this point, we conclude that cortical thickness should be considered as an important and until now not recognized modulating factor in studies employing non-invasive brain stimulation techniques. (c) 2012 Elsevier Inc. All rights reserved.