The effect of the weather on pulmonary exacerbations and viral infections among adults with cystic fibrosis
The effect of the weather on pulmonary exacerbations and viral infections among adults with cystic fibrosis
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DOI：
10.1007/s00484-013-0786-0
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发表时间：
2014-11-01
影响因子：
3.2
通讯作者：
Jones, A. M.
中科院分区：
文献类型：
--
作者：
Flight, W. G.;Bright-Thomas, R. J.;Jones, A. M.
天气变化对囊性纤维化（CF）患者呼吸系统健康的影响尚不清楚。我们进行了一项前瞻性研究，以确定气候和季节对成人 CF 病毒性呼吸道感染 (VRI) 和肺部病情加重 (PEx) 发病率的影响。 2010 年 12 月至 2012 年 4 月期间，对 98 名患有 CF 的成年人进行了为期 12 个月的随访。每 2 个月以及在 PEx 开始时另外对痰液、鼻腔和咽喉拭子进行针对 9 种病毒的聚合酶链反应测定。在整个研究过程中记录每小时的温度和相对湿度测量值。统计分析利用广义估计方程（GEE）模型。分别有 29% 和 37% 的访问符合预先指定的 VRI 和 PEx 标准。鼻病毒占已识别病毒的 72%。鼻病毒的发病率在秋季达到高峰，而非鼻病毒 VRI 的发病率在冬季达到高峰。鼻病毒与平均温度升高相关（OR 1.07；p=0.001），而非鼻病毒 VRI 与平均温度降低相关（OR 0.87；p=0.001）。
The effect of changes in the weather on the respiratory health of patients with cystic fibrosis (CF) is unclear. We conducted a prospective study to determine the impact of climate and season on the incidence of viral respiratory infections (VRI) and pulmonary exacerbations (PEx) among adults with CF. Between December 2010 and April 2012, 98 adults with CF were followed for 12 months. Polymerase chain reaction assays for nine viruses were performed on sputum, nose and throat swabs every 2 months and additionally at onset of PEx. Hourly temperature and relative humidity measurements were recorded throughout the study. Statistical analysis utilized generalized estimating equation (GEE) models. Pre-specified criteria for VRI and PEx were met at 29 % and 37 % of visits, respectively. Rhinovirus accounted for 72 % of identified viruses. Incidence of rhinovirus peaked in autumn while non-rhinovirus VRI peaked in winter. Rhinovirus was associated with increased mean temperatures (OR 1.07; p=0.001), while non-rhinovirus VRI was associated with lower mean temperatures (OR 0.87; p