The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma.

The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma.
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Epstein-Barr病毒编码的microRNA在鼻咽癌中的新作用

DOI:
10.7150/jca.25460
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发表时间:
2018
期刊:
影响因子:
3.9
通讯作者:
Zeng Z
Zeng Z
中科院分区:
医学3区
文献类型:
--
作者:
Fan C;Tang Y;Wang J;Xiong F;Guo C;Wang Y;Xiang B;Zhou M;Li X;Wu X;Li Y;Li X;Li G;Xiong W;Zeng Z

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Epstein-Barr virus (EBV) is an oncogenic herpes virus that is closely associated with the initiation and development of nasopharyngeal carcinoma (NPC), lymphoma and other malignant tumors. EBV encodes 44 mature miRNAs that regulate viral and host cell gene expression and plays a variety of roles in biological functions and the development of cancer. In this review, we summarized the biological functions and molecular mechanisms of Epstein-Barr virus-encoded microRNAs (EBV miRNAs) in tumor immune evasion, proliferation, anti-apoptosis, invasion, metastasis and as a potential biomarker for NPC diagnosis and prognosis. The knowledge generated by EBV miRNAs can be used for EBV miRNA-based precision cancer treatments in the near future.
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