The in vitro Effect of Normal and Immune Serum upon the Cercariæ of Schistosoma mansoni
The in vitro Effect of Normal and Immune Serum upon the Cercariæ of Schistosoma mansoni
复制标题
正常血清和免疫血清对曼氏血吸虫尾蚴的体外影响
DOI：
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发表时间：
1952
影响因子：
1.6
通讯作者：
O. D. Standen
中科院分区：
文献类型：
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作者：
O. D. Standen
大多数正常血清在体外对曼氏血吸虫幼虫有杀灭作用。502份正常血清中。21%的人没有杀龋力，而其余的人表现出不同程度的杀龋力。杀螨因子不耐热，在储存过程中消失。作为补充，它有几个相似之处。在所调查的所有物种的血清中都存在不同程度的杀尾因子。所有牛和其他物种的不同比例的血清表面上看是正常的，导致尾蚴周围形成了包绕的沉淀物。这与线虫负担或肝片吸虫的存在没有明显的关系。曼氏血吸虫尾蚴周围形成的包膜沉淀物，放置在免疫血清中，在87℃下孵育，这种沉淀物既存在于免疫曼氏血吸虫的血清中，也存在于免疫血吸虫的血清中。目前尚不清楚感染的年龄和体重是否会影响包膜沉淀的速度和程度。
The majority of normal sera proved in vitro to be cercaricidal to larvae of S. mansoni. Of 502 normal sera. 21 per cent, were noncercaricidal whereas the remainder exhibited varying degrees of cercaricidal potency. The cercaricidal factor was thermolabile and disappeared during storage. It bore several points of similarity to complement. The cercaricidal factor was present to a varying degree in sera from all species investigated. Apparently normal sera from all cattle and different proportions of other species, caused an enveloping precipitate to form around the cercariae. This bore no obvious relationship to the nematode worm burden or presence of F. hepatica. An enveloping precipitate formed around cercariae of S. mansoni when placed in vitro in immune sera and incubated at 87°C. This occurred in serum immune to S. haematobium as well as to S. mansoni. It is not known-whether age and weight of infection influence the rate and extent of envelope precipitation.