Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers
Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers
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DOI：
10.1093/aje/153.7.680
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发表时间：
2001-04-01
影响因子：
5
通讯作者：
Albanes, D
中科院分区：
文献类型：
--
作者：
Stolzenberg-Solomon, RZ;Pietinen, P;Albanes, D
作者在α-生育酚、β-胡萝卜素癌症预防研究队列中前瞻性地研究了膳食叶酸和其他已知影响甲基基团可用性的因素是否与外分泌胰腺癌的发生有关。在 27,101 名 50-69 岁的健康男性吸烟者中，他们在基线时完成了自我管理的饮食调查问卷，其中 157 人在 1985 年至 1997 年长达 13 年的随访期间患上胰腺癌。Cox 比例风险模型用于估计风险比和 95% 置信区间。比较膳食叶酸摄入量最高和最低五分位数的调整后风险比为 0.52（95% 置信区间：0.31，0.871 p 趋势 = 0.05）。饮食中的蛋氨酸、酒精摄入量和吸烟史并没有改变这种关系。膳食蛋氨酸、维生素 B-6 和 B-12 或酒精摄入量与胰腺癌风险之间没有观察到显着关联。与之前的研究一致，本研究表明吸烟与风险增加相关（与最低五分位相比，每天吸烟最高：风险比 = 1.82；95% 置信区间：1.10、3.03；p 趋势 = 0.05）。这些结果支持了膳食叶酸摄入量与胰腺癌风险呈负相关的假设，并证实了与更多吸烟相关的风险。
The authors examined prospectively whether dietary folate and other factors known to influence methyl-group availability were associated with the development of exocrine pancreatic cancer within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort. Of the 27,101 healthy male smokers aged 50-69 years who completed a self-administered dietary questionnaire at baseline, 157 developed pancreatic cancer during up to 13 years of follow-up from 1985 to 1997. Cox proportional hazards models were used to estimate the hazards ratios and 95% confidence intervals. The adjusted hazards ratio comparing the highest with the lowest quintile of dietary folate intake was 0.52 (95% confidence interval: 0,31, 0.871 p-trend = 0.05). Dietary methionine, alcohol intake, and smoking history did not modify this relation. No significant associations were observed between dietary methionine, vitamins B-6 and B-12, or alcohol intake and pancreatic cancer risk. Consistent with prior studies, this study shows that cigarette smoking was associated with an increased risk (highest compared with lowest quintile, cigarettes per day: hazards ratio = 1.82; 95% confidence interval: 1.10, 3.03; p-trend = 0.05). These results support the hypothesis that dietary folate intake is inversely associated with the risk of pancreatic cancer and confirm the risk associated with greater cigarette smoking.