Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
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DOI：
10.1038/s41551-019-0465-5
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发表时间：
2020-01-01
影响因子：
28.1
通讯作者：
Whitehead, Kathryn A.
中科院分区：
文献类型：
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作者：
Lamson, Nicholas G.;Berger, Adrian;Whitehead, Kathryn A.
生物活性肽和蛋白质的口服递送被肠上皮屏障阻止，其中细胞间紧密连接复合物阻断大分子的摄取。在这里，我们表明，阴离子纳米粒子诱导紧密连接松弛，增加肠道通透性，使蛋白质的口服输送。这种渗透增强效应是纳米颗粒尺寸和电荷的函数，较小的（
The oral delivery of bioactive peptides and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecules. Here we show that anionic nanoparticles induce tight junction relaxation, increasing intestinal permeability and enabling the oral delivery of proteins. This permeation-enhancing effect is a function of nanoparticle size and charge, with smaller (