EFFECT OF NIFEDIPINE ON TOTAL ISCHEMIC ACTIVITY AND CIRCADIAN DISTRIBUTION OF MYOCARDIAL ISCHEMIC EPISODES IN ANGINA-PECTORIS
EFFECT OF NIFEDIPINE ON TOTAL ISCHEMIC ACTIVITY AND CIRCADIAN DISTRIBUTION OF MYOCARDIAL ISCHEMIC EPISODES IN ANGINA-PECTORIS
复制标题
DOI：
10.1016/0002-9149(91)90433-l
复制
发表时间：
1991-01-15
影响因子：
2.8
通讯作者：
HEGARTY, P
中科院分区：
文献类型：
--
作者：
NESTO, RW;PHILLIPS, RT;HEGARTY, P
A randomized, double-blind, crossover study was conducted in 10 patients to assess the effect of nifedipine versus placebo on total ischemic activity and circadian distribution of ischemic episodes. After baseline exercise treadmill testing and 48-hour ambulatory electrocardiographic ST-segment monitoring, patients received either nifedipine (mean dose, 80 mg/day) or placebo administered 4 times per day, with the initial dose taken immediately upon arising in the morning. Patients were maintained on a stable dose of each study drug for 7 days, after which they underwent repeat exercise treadmill testing and 48-hour ambulatory electrocardiography. During exercise treadmill testing, greater exercise duration was achieved by patients receiving nifedipine than by those receiving placebo (421 +/- 121 vs 353 +/- 155 seconds, respectively; p < 0.05). Time to greater-than-or-equal-to 1 mm ST depression was significantly greater with nifedipine (282 +/- 146 seconds) than at baseline (130 +/- 72 seconds, p < 0.003) and with placebo (150 +/- 98 seconds, p < 0.0005). During ambulatory electrocardiographic monitoring, nifedipine reduced both the total number of ischemic episodes (18 vs 54 at baseline and 63 with placebo; p < 0.02 for both) and the total duration of ischemia (260 vs 874 at baseline and 927 minutes with placebo; p < 0.02 for both). The surge of ischemia between 06:00 and 12:00 noted at baseline and during placebo therapy was nearly abolished during nifedipine treatment. Nifedipine at this dosage, administered in this manner, is effective in reducing total ischemic activity and may prevent morning surges of ischemic episodes.
