The statistical analysis of partially confounded covariates important to neural spiking
The statistical analysis of partially confounded covariates important to neural spiking
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DOI：
10.1016/j.jneumeth.2011.12.021
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发表时间：
2012-04-15
影响因子：
3
通讯作者：
Eden, Uri T.
中科院分区：
文献类型：
--
作者：
Lepage, Kyle Q.;MacDonald, Christopher J.;Eden, Uri T.
提出了一种能够消除统计协变量对神经尖峰活动的相对影响的方法。该方法是 Truccolo 等人引入的广义线性模型 (GLM) 方法的扩展。 （2005）为了分析神经尖峰数据，利用了由 GLM 最大似然参数估计器的 Fisher 信息中存在的几何图形驱动的投影操作。通过利用这些预测，神经活动可以分为三类。这三个类别，仅由一组感兴趣的协变量引起的神经活动，仅由一组无趣或讨厌的协变量引起的神经活动，以及不能明确分配给任一组协变量的神经活动，可以与时间、位置、头部方向和速度等物理变量相关联。这种关联允许对神经活动进行分析，例如，神经活动可能仅归因于时间影响，而不考虑其他已识别的影响。该方法应用于模拟老鼠探索时间调制的位置场。 MacDonald 等人报告了部分分析。 (2011)，使用本文描述的方法进行复制。该分析表明，通过啮齿动物海马体中存在的细胞的放电活动，在顺序记忆任务中延迟期的时间桥接无法用啮齿动物的位置、头部方向或速度来解释。 (C) 2012 Elsevier B.V. 保留所有权利。
A method is presented capable of disambiguating the relative influence of statistical covariates upon neural spiking activity. The method, an extension of the generalized linear model (GLM) methodology introduced in Truccolo et al. (2005) to analyze neural spiking data, exploits projection operations motivated by a geometry present in the Fisher information of the GLM maximum likelihood parameter estimator. By exploiting these projections, neural activity can be divided into three categories. These three categories, neural activity due solely to a set of covariates of interest, neural activity due solely to a set of uninteresting, or nuisance, covariates, and neural activity that cannot be unequivocally assigned to either set of covariates, can be associated with physical variables such as time, position, head-direction and velocity. This association allows the analysis of neural activity that can, for example, be due solely to temporal influence, irrespective of other, identified, influences. The method is applied in simulation to a rat exploring a temporally modulated place field. A portion of the analysis reported in MacDonald et al. (2011), using the methodology described herein, is reproduced. This analysis demonstrates the temporal bridging of a delay period in a sequential memory task by firing activity of cells present in the rodent hippocampus that cannot be explained by rodent position, head direction or velocity. (C) 2012 Elsevier B.V. All rights reserved.