Bio-based molecular imprinted polymers for separation and purification of chlorogenic acid extracted from food waste
Bio-based molecular imprinted polymers for separation and purification of chlorogenic acid extracted from food waste
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DOI：
10.1016/j.seppur.2023.124857
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发表时间：
2023-08
影响因子：
8.6
通讯作者：
Yagya Gupta;Laura E Beckett;Sunitha Sadula;V. Vargheese;L. Korley;D. Vlachos
中科院分区：
文献类型：
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作者：
Yagya Gupta;Laura E Beckett;Sunitha Sadula;V. Vargheese;L. Korley;D. Vlachos
食物浪费是一个深刻的挑战，因为全球粮食产量的17%（即，9.31亿吨）每年都成为废物。一种具有成本效益的策略是从食物垃圾中提取高价值的酚酸，但由于其相似的化学性质，高沸点和复杂混合物中的低浓度，其下游纯化具有挑战性。在此，我们提出了分离目标酚分子印迹聚合物。合成过程中单体-模板复合物的稳定性对于优化聚合物选择性和性能至关重要。采用真实的溶剂类导体筛选模型（COSMO-RS）和汉森溶解度参数（HSPiP）计算方法，对28种单体和13种致孔溶剂与绿原酸的相互作用进行了筛选。实验表明，衣康酸，功能单体，和四氢呋喃（THF），合成溶剂，提供了最高的分离因子。该聚合物在浓度高达1 mg/mL的浓溶液中对绿原酸表现出上级选择性，并且其对各种官能团的高灵敏度使得能够有效分离所有目标酚酸。聚合物的性能进行了评估，在不同的萃取溶剂，傅立叶变换红外（FTIR）的研究表明，聚合物-溶剂相互作用的关键因素影响其性能。应用该聚合物从咖啡豆和马铃薯皮提取物中提纯绿原酸，纯度可达92%，并对其重复使用性进行了评价。与目前生产混合物的工业净化方法相比，基于实验室规模的技术经济分析，所提出的技术提供了至少11倍的经济价值和95%的碳排放量。
Food waste is a profound challenge as 17% of global food production (i.e., 931 million tons) ends up as waste yearly. A cost-effective strategy is the extraction of high-value phenolic acids from food waste, but their downstream purification is challenging owing to their similar chemical nature, high boiling points, and low concentrations in complex mixtures. Herein, we propose separating target phenolics using molecular imprinted polymers. The stability of the monomer-template complex during the synthesis is critical in optimizing the polymer selectivity and performance. COnductor like Screening MOdel for Real Solvents (COSMO-RS) and Hansen Solubility Parameters in Practice (HSPiP) computations were used to screen the interaction of 28 monomers and 13 porogenic solvents with chlorogenic acid as the target molecule. Experiments revealed that itaconic acid, the functional monomer, and tetrahydrofuran (THF), the synthesis solvent, provide the highest reported separation factor. The polymer exhibits superior selectivity towards chlorogenic acid in concentrated solutions of up to 1 mg/mL, and its high sensitivity to various functionalities enables the effective separation of all target phenolic acids. The polymer's performance was evaluated in different extraction solvents, and Fourier transform infrared (FTIR) studies revealed polymer–solvent interaction as the critical factor influencing its performance. The application of the polymer in purifying up to 92% chlorogenic acid from coffee beans and potato peel waste extractives is demonstrated, and its reusability is evaluated. In contrast to the current industrial purification methodology that produces mixtures, the proposed technology provides at least eleven times higher economic value and 95% less carbon emissions based on lab-scale techno-economic analysis.