EFFECTS OF ANTIEPILEPTIC DRUGS ON ABSENCE-LIKE AND TONIC SEIZURES IN THE SPONTANEOUSLY EPILEPTIC RAT, A DOUBLE MUTANT RAT
EFFECTS OF ANTIEPILEPTIC DRUGS ON ABSENCE-LIKE AND TONIC SEIZURES IN THE SPONTANEOUSLY EPILEPTIC RAT, A DOUBLE MUTANT RAT
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DOI：
10.1111/j.1528-1157.1988.tb03754.x
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发表时间：
1988-09-01
期刊：
影响因子：
5.6
通讯作者：
YAMADA, J
中科院分区：
文献类型：
--
作者：
SASA, M;OHNO, Y;YAMADA, J
脑电图 (EEG) 研究旨在检查几种抗癫痫药物 (AEDS) 对自发性癫痫大鼠 (SER: zi/zi, tm/tm) 的失神样和强直性癫痫发作的影响，该大鼠是一种双突变体大鼠，通过震颤杂合子动物 (tm/+) 与 zitter 纯合子动物 (zi/zi) 交配获得，并确定 SER 中的癫痫发作是否对应于人类失神和强直性癫痫发作。强直性癫痫发作。使用植入电极连续记录额叶皮层和海马体的自发脑电图。在失神状态期间，SER 在皮质和海马脑电图上显示出阵发性、同步的 5-7-Hz 尖峰波状复合体，其特征是不动和凝视。动物在没有外部刺激的情况下也表现出强直性惊厥，并伴有皮质和海马脑电图上的低电压快波。在一些动物中，强直性惊厥期间低压快波中出现零星的低振幅尖峰。三甲二酮（100 mg/kg 腹腔注射，腹腔注射）和乙舒昔米（100 mg/kg 腹腔注射）可抑制失神样癫痫发作，而强直惊厥不受这些药物的影响。相比之下，苯妥英（20 mg/kg i.p.）抑制强直性癫痫发作，但不影响失神样癫痫发作。苯巴比妥（10 mg/kg，腹腔注射）和丙戊酸钠（200 mg/kg，腹腔注射）对两种癫痫发作的抑制程度相似。这些结果表明，具有失神样癫痫发作和强直性癫痫发作的 SER 是评估 AEDS 的有用模型。
Electroencephalographic (EEG) studies were performed to examine the effects of several antiepileptic drugs (AEDS) on absence-like and tonic seizures in the spontaneously epileptic rat (SER: zi/zi, tm/tm), a double mutant rat, which was obtained by mating the tremor heterozygous animals (tm/+) with the zitter homozygous animals (zi/zi), and to determine whether the seizures in the SER correspond to human absence and tonic seizures. Spontaneous EEG was continuously recorded from the frontal cortex and hippocampus using implanted electrodes. The SER showed paroxysmal and synchronized 5-7-Hz spike-wave-like complexes in both cortical and hippocampal EEG during the absence-like state, which was characterized by immobility and staring. The animals also exhibited tonic convulsion without external stimulation concomitant with low-voltage fast waves on cortical and hippocampal EEG. In some animals, sporadic low-amplitude spikes appeared in the low-voltage fast waves during tonic convulsion. The absence-like seizures were inhibited by trimethadione (100 mg/kg intraperitoneally, i.p.) and ethosuximide (100 mg/kg i.p.), whereas the tonic convulsion was not affected by these drugs. In contrast, phenytoin (20 mg/kg i.p.) inhibited the tonic seizures without affecting the absence-like seizures. Phenobarbital (10 mg/kg i.p.) and valproate (200 mg/kg i.p.) inhibited both seizures to a similar degree. These results suggest that the SER, with both absence-like and tonic seizures, is a useful model for evaluation of AEDS.