Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography
Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography
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DOI：
10.1099/0022-1317-82-8-1867
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发表时间：
2001-08-01
影响因子：
3.8
通讯作者：
Gould, EA
中科院分区：
文献类型：
--
作者：
Gaunt, MW;Sall, AA;Gould, EA
系统发育分析的黄病毒属，使用非结构5基因或结构包膜基因的部分序列，揭示了一系列广泛的分支定义的流行病学和疾病的关联。这些基因组学鉴定了蚊媒、蜱媒和未知载体（NKV）病毒的进化枝，这些进化枝可以进一步细分为由其主要脊椎动物宿主定义的进化枝。蚊媒黄病毒揭示了两个不同的流行病学组：（i）嗜神经性病毒，通常与人类或牲畜的脑炎疾病相关，与库蚊属媒介和鸟类宿主相关;（ii）非嗜神经性病毒，与人类的出血性疾病相关，与伊蚊属媒介和灵长类宿主相关。因此，树拓扑结构描述的病毒宿主协会可能反映了伊蚊和库蚊之间的喂养行为的差异。蜱传病毒也形成了两个不同的组：一组与海鸟有关，另一组是蜱传脑炎复合病毒，主要与啮齿动物有关。NKV黄病毒形成了三个不同的组：一组与蚊子传播的病毒密切相关，与蝙蝠有关;第二组在遗传上更遥远，也与蝙蝠有关;第三组与啮齿动物有关。每个流行病学组在旧世界或新世界揭示了不同的地理集群，这对于蚊媒病毒可能反映了旧世界的起源。流行病学、疾病相关性和地理学之间的相互关系开始定义病毒、媒介、脊椎动物宿主和生态位之间复杂的进化关系。
Phylogenetic analysis of the Flavivirus genus, using either partial sequences of the non-structural 5 gene or the structural envelope gene, revealed an extensive series of clades defined by their epidemiology and disease associations. These phylogenies identified mosquito-borne, tick-borne and no-known-vector (NKV) virus clades, which could be further subdivided into clades defined by their principal vertebrate host. The mosquito-borne flaviviruses revealed two distinct epidemiological groups: (i) the neurotropic viruses, often associated with encephalitic disease in humans or livestock, correlated with the Culex species vector and bird reservoirs and (ii) the non-neurotropic viruses, associated with haemorrhagic disease in humans, correlated with the Aedes species vector and primate hosts. Thus, the tree topology describing the virus-host association may reflect differences in the feeding behaviour between Aedes and Culex mosquitoes. The tick-borne viruses also formed two distinct groups: one group associated with seabirds and the other, the tick-borne encephalitis complex viruses, associated primarily with rodents. The NKV flaviviruses formed three distinct groups: one group, which was closely related to the mosquito-borne viruses, associated with bats; a second group, which was more genetically distant, also associated with bats; and a third group associated with rodents. Each epidemiological group within the phylogenies revealed distinct geographical clusters in either the Old World or the New World, which for mosquito-borne viruses may reflect an Old World origin. The correlation between epidemiology, disease correlation and biogeography begins to define the complex evolutionary relationships between the virus, vector, vertebrate host and ecological niche.