Evidence supporting the match/mismatch hypothesis of psychiatric disorders
Evidence supporting the match/mismatch hypothesis of psychiatric disorders
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DOI：
10.1016/j.euroneuro.2014.02.002
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发表时间：
2014-06-01
影响因子：
5.6
通讯作者：
Schmidt, Mathias V.
中科院分区：
文献类型：
--
作者：
Santarelli, Sara;Lesuis, Sylvie L.;Schmidt, Mathias V.
慢性应激是许多精神疾病的主要环境风险因素之一，尤其是对严重的抑郁症。不同的假说已经被用来解决早期和成年慢性应激在精神疾病脆弱性中的相互作用。精神疾病的匹配/不匹配假说指出，早期的生活环境塑造了应对策略，使个人能够在以后的生活中以最佳方式面对类似的环境。我们在雌性Balb/c小鼠身上测试了这一假设，这些小鼠在生命早期经历了压力或丰富，并在成年后进一步细分为单独或集体饲养，以分别提供厌恶或积极的成年环境。我们研究了环境操纵对焦虑、抑郁和社交行为以及基因表达谱的影响。我们表明，与持续的支持性环境(匹配条件)相比，持续暴露于不利环境(匹配条件)并不一定导致相反的表型。相反，环境条件不匹配的动物在焦虑、社交和抑郁等表型上的表现与环境匹配的动物不同。这些结果进一步支持了匹配/不匹配假说，并说明了发育过程中轻微或适度的厌恶条件如何塑造一个人，使其在以后的生活中以最佳方式适应类似的条件。(C)2014年爱思唯尔和ECNP。版权所有。
Chronic stress is one of the predominant environmental risk factors for a number of psychiatric disorders, particularly for major depression. Different hypotheses have been formulated to address the interaction between early and adult chronic stress in psychiatric disease vulnerability. The match/mismatch hypothesis of psychiatric disease states that the early life environment shapes coping strategies in a manner that enables individuals to optimally face similar environments later in life. We tested this hypothesis in female Balb/c mice that underwent either stress or enrichment early in life and were in adulthood further subdivided in single or group housed, in order to provide aversive or positive adult environments, respectively. We studied the effects,of the environmental manipulation on anxiety-like, depressive-like and sociability behaviors and gene expression profiles. We show that continuous exposure to adverse environments (matched condition) is not necessarily resulting in an opposite phenotype compared to a continuous supportive environment (matched condition). Rather, animals with mismatched environmental conditions behaved differently from animals with matched environments on anxious, social and depressive like phenotypes. These results further support the match/mismatch hypothesis and illustrate how mild or moderate aversive conditions during development can shape an individual to be optimally adapted to similar conditions later in life. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.