Improved survival rate after myocardial infarction using an inducible cholesterol efflux (iCE) peptide: FAMP.
Improved survival rate after myocardial infarction using an inducible cholesterol efflux (iCE) peptide: FAMP.
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DOI：
10.1016/j.ijchv.2014.05.005
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Saku K
中科院分区：
文献类型：
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作者：
Yahiro E;Uehara Y;Kawachi E;Ando S;Miura SI;Saku K
载脂蛋白（apo）A-I模拟肽改善心肌梗死（MI）后生存率的研究未见报道。对雄性C57 Bl/6 J小鼠进行左冠状动脉永久结扎作为MI模型。我们合成了一个新的24个氨基酸的apoA-I模拟肽5（FAMP 5），它通过特异性ATP结合盒转运蛋白A1（ABCA 1）有效地清除胆固醇。与对照组相比，FAMP 5通过防止心脏破裂而与显著改善的存活率相关。在FAMP 5处理组的心脏中，eNOS、加塔-4、CTGF和ANP的mRNA水平显著增加，而MCP-1的mRNA水平降低。这是第一个报告，高密度脂蛋白（HDL）治疗与FAMP 5改善MI后的生存率。
There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI). Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino acid apoA-I mimetic peptide-type5 (FAMP5), which potently removes cholesterol via specific ATP-binding cassette transporter A1 (ABCA1). FAMP5 was associated with a significantly improved survival rate by protecting against cardiac rupture compared to the control. mRNA levels for eNOS, Gata-4, CTGF and ANP were significantly increased in the hearts of the FAMP5-treated group, while that for MCP-1 decreased. This is the first report that high-density lipoprotein (HDL) therapy with FAMP5 improved the survival rate after MI.