Folate and clefts of the lip and palate - A UK-based case-control study: Part I: Dietary and supplemental folate
Folate and clefts of the lip and palate - A UK-based case-control study: Part I: Dietary and supplemental folate
复制标题
DOI：
10.1597/06-150.1
复制
发表时间：
2008-07-01
影响因子：
1.1
通讯作者：
Fryer, A. E.
中科院分区：
文献类型：
--
作者：
Little, J.;Gilmour, M.;Fryer, A. E.
目的：我们试图确定患有或不患有腭裂 (CL +/- P) 和单纯腭裂 (CP) 的非综合征性唇裂 (CL +/- P) 与母亲膳食叶酸和补充叶酸摄入量之间的关联，该地区出生时神经管缺陷的患病率很高，并且面粉中未强化叶酸。方法：对 112 CL +/- P 的母亲完成了有关围孕期饮食摄入和补充剂使用的访谈。例，78 例 CP 例，以及 248 例未受影响的婴儿。通过逻辑回归方法对数据进行分析。结果：CL +/- P 和 CP 与能量调整的总叶酸摄入量或补充叶酸的使用（无论剂量如何）之间没有总体关联。结论：总体而言，较高的总叶酸摄入量似乎并不能预防该人群的口裂。
Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.