Diet and Parkinson's disease:: A potential role of dairy products in men
Diet and Parkinson's disease:: A potential role of dairy products in men
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DOI：
10.1002/ana.10381
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发表时间：
2002-12-01
影响因子：
11.2
通讯作者：
Ascherio, A
中科院分区：
文献类型：
--
作者：
Chen, HL;Zhang, SMM;Ascherio, A
饮食可能在帕金森病（PD）中起致病作用，但在前瞻性研究中很少评估饮食与PD风险之间的潜在关联。我们在两个大型前瞻性队列中调查了食物摄入量与PD风险之间的关系，其中记录了210例男性和184例女性PD病例。男性乳制品摄入量与PD风险呈正相关（相对风险[RR]比较极端类别，1.8；p趋势= 0.004），但女性没有（RR, 1.1； p趋势= 0.9）。没有其他食物组与男性或女性患帕金森病的风险相关。对男性的进一步分析显示，摄入几种乳制品以及乳制品钙（RR, 1.5； p趋势= 0.02）、乳制品维生素D （RR, 1.6； p趋势= 0.004）、乳制品蛋白（RR, 1.6； p趋势= 0.01）和乳糖（RR, 1.8； p趋势= 0.002）与PD风险显著正相关，但与乳制品脂肪（RR, 1.1； p趋势= 0.4）无关。从其他膳食或补充来源摄入钙、维生素D和蛋白质与男性帕金森病风险无关。我们的研究结果表明，摄入更多的乳制品可能会增加男性患帕金森病的风险；然而，这一发现需要进一步评估，并且需要确定潜在的有效成分。
Diet may play a causative role in Parkinson's disease (PD), but potential associations between diet and PD risk rarely have been assessed in prospective studies. We investigated associations between food intakes and PD risk in two large prospective cohorts in which 210 incident PD cases in men and 184 in women were documented. A positive association was found between dairy intake and PD risk in men (relative risk [RR] comparing extreme categories, 1.8; p trend = 0.004), but not in women (RR, 1.1; p trend = 0.9). No other food groups were associated with PD risk in either men or women. Further analyses among men showed significant positive associations with PD risk for intakes of several dairy foods as well as dairy calcium (RR, 1.5; p trend = 0.02), dairy vitamin D (RR, 1.6; p trend = 0.004), dairy protein (RR, 1.6; p trend = 0.01), and lactose (RR, 1.8; p trend = 0.002), but not dairy fat (RR, 1.1; p trend = 0.4). Intakes of calcium, vitamin D, and protein from other dietary or supplemental sources were not related to PD risk in men. Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified.