The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function
The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function
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DOI：
10.1046/j.1528-1157.2002.49901.x
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发表时间：
2002-09-01
期刊：
影响因子：
5.6
通讯作者：
Magnotta, V
中科院分区：
文献类型：
--
作者：
Hermann, B;Seidenberg, M;Magnotta, V
目的：比较儿童期发作的颞叶癫痫与晚发慢性颞叶癫痫和健康对照的脑结构和认知功能的神经发育相关性。方法：健康对照组（n = 62）和颞叶癫痫发作年龄早（n = 37）与晚（n = 16）的患者进行了高分辨率定量磁共振成像（MRI）比较容量测量和综合神经心理学评估。结果：儿童期颞叶癫痫患者（平均发病年龄7.8岁）与健康对照组和晚发性颞叶癫痫患者相比，表现出广泛的神经心理学表现受损和延伸至颞外区域的脑组织体积显著减少（平均发病年龄，23.3岁），最明显的是减少总白质体积在儿童期发病的患者。减少脑组织体积，特别是总白质体积，与显着较差的认知状态，证明在体积abnormalities.Conclusions的临床意义：儿童期发作的颞叶癫痫似乎与不良的神经发育影响油脑结构和认知，出现广义的性质，特别是在白质组织体积。
Purpose: To characterize the neurodevelopmental correlates of childhood-onset temporal lobe epilepsy on brain structure and cognition compared with late-onset chronic temporal lobe epilepsy and healthy controls.Methods: Healthy controls (n = 62) and patients with early (n = 37) versus late (n = 16) age at onset of temporal lobe epilepsy were compared with high-resolution quantitative magnetic resonance imaging (MRI) volumetrics and comprehensive neuropsychological assessment.Results: Patients with childhood-onset temporal lobe epilepsy (mean onset age, 7.8 years) exhibited widespread compromise in neuropsychological performance and substantial reduction in brain tissue volumes extending to extratemporal regions compared with healthy controls and late-onset temporal lobe epilepsy patients (mean onset age, 23.3 years), Most evident was reduced total white-matter volume among the childhood-onset patients. Reduction in brain tissue Volume, especially total white-matter volume, was associated with significantly poorer cognitive status, attesting in the clinical significance of the volumetric abnormalities.Conclusions: Childhood-onset temporal lobe epilepsy appears to be associated with an adverse neurodevelopmental impact oil brain structure and cognition that appears generalized in nature and and especially in white-matter tissue volume.