OCT angiography findings in children with amblyopia
OCT angiography findings in children with amblyopia
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DOI：
10.1016/j.jaapos.2018.03.009
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发表时间：
2018-08-01
期刊：
影响因子：
1.6
通讯作者：
Castela, Rui
中科院分区：
文献类型：
--
作者：
Sobral, Isa;Rodrigues, Tiago M.;Castela, Rui
目的应用光学相干断层扫描血管成像(OCT-A)技术对弱视儿童对侧眼和对照眼的显微结构和血管密度进行比较。方法采用OCT-A(Avanti RTVue XR，Optovue Inc.，加利福尼亚州弗里蒙特)对弱视儿童黄斑和视盘血管密度和血流面积进行前瞻性、横断面评价。结果共纳入52名儿童，其中弱视组26名，非弱视对照组26名。弱视眼患者的黄斑浅毛细血管丛血管密度(P=0.0171)、视盘血流面积(P=0.0195)和视网膜神经纤维层平均厚度(P=0.0194)均显著降低，而黄斑毛细血管网血流面积(P=0.0305)和视盘平均光密度(P=0.0279)均有统计学意义的下降。与随机选择的对照组相比，弱视眼的黄斑血流面积(P=0.005)和深部毛细血管丛(P=0.002)、黄斑血管密度(P=0.022)、视盘血流面积(P=0.004)、黄斑中心凹无血管区面积(P=0.038)均有显著差异。这些发现的临床意义值得进一步研究。
PURPOSE To compare the microstructure and vascularity of amblyopic eyes in children with their contralateral eye and with eyes from control children using optical coherence tomography angiography (OCT-A).METHODS We conducted a prospective, cross-sectional evaluation of macular and optic disk vascular density and flow area using OCT-A (Avanti RTVue XR, Optovue Inc, Fremont, CA). Parameters were calculated using automated software.RESULTS A total of 52 children were included: 26 subjects with amblyopia and 26 nonamblyopic controls. The amblyopic eye of subjects showed a statistically significant decrease in macular vascular density (P = 0.0171) of the superficial capillary plexus (SCP), in the optic disk flow area (P = 0.0195) and in the average retinal nerve fiber layer thickness (P = 0.0194) as well as a marginally statistically significant decrease in the macular flow area of the SCP (P = 0.0305) and in the optic density (P = 0.0279). Compared with randomly selected eyes of controls, amblyopic eyes showed a statistically significant decrease in the macular flow area of the SCP (P = 0.005) and of the deep capillary plexus (DCP; P = 0.002), in the macula vascular density of the SCP (P = 0.022), in the optic disk flow area (P = 0.004), and a marginally statistical significant increase in the area of foveal avascular zone of the DCP (P = 0.038).CONCLUSIONS In our study cohort amblyopic eyes manifested significant differences in macular and optic disk vascularization. The clinical significance of these findings warrants further research.