Serum dipeptidyl peptidase 4 activity in children with type 1 diabetes mellitus
Serum dipeptidyl peptidase 4 activity in children with type 1 diabetes mellitus
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DOI：
10.1515/jpem-2013-0122
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发表时间：
2016-10
期刊：
影响因子：
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通讯作者：
Atsushi Iwabuchi;T. Kamoda;M. Saito;H. Nozue;I. Izumi;T. Hirano;R. Sumazaki
中科院分区：
文献类型：
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作者：
Atsushi Iwabuchi;T. Kamoda;M. Saito;H. Nozue;I. Izumi;T. Hirano;R. Sumazaki
摘要背景：目前尚不清楚二肽基肽酶4（DPP 4）活性是否改变，以及DPP 4如何有助于1型糖尿病（T1 DM）患者的血糖控制。目的：本研究的目的是测量T1 DM儿童的血清DPP 4活性并评估其与代谢变量的关系。方法：采用荧光法测定43例T1 DM患儿和26例对照组儿童血清中DPP 4活性。结果：T1 DM患儿血清DPP 4活性显著高于对照组（3.57±0.99 vs. 2.67±0.77 U/mL，p<0.001）。在T1 DM儿童中，DPP 4活性与HbA 1c、血糖或糖尿病病程无关。2型糖尿病组DPP 4活性与血清脂联素水平呈显著负相关（r=-0.35，p = 0.05）。结论：T1 DM患儿血清DPP 4活性升高，但与血糖控制无关。鉴于血清DPP 4和脂联素水平之间的负相关性，需要进一步研究以阐明DPP 4在T1 DM儿童胰岛素敏感性中的作用。
Abstract Background: It is poorly understood whether dipeptidyl peptidase 4 (DPP4) activity is altered and how DPP4 contributes to glycemic control in patients with type 1 diabetes mellitus (T1DM). Aim: The aim of this study was to measure serum DPP4 activity and to assess its relationships to metabolic variables in T1DM children. Methods: Serum DPP4 activity was determined using a fluorometric assay in 43 T1DM and 26 control children. Results: Serum DPP4 activity was significantly higher in T1DM children than in controls (3.57±0.99 vs. 2.67±0.77 U/mL, p<0.001). In the T1DM children, DPP4 activity was not correlated with HbA1c, blood glucose, or diabetes duration. A significant negative correlation was found between DPP4 activity and serum adiponectin levels in the T1DM group (r=–0.35, p<0.05). Conclusions: Serum DPP4 activity was increased in the T1DM children, whereas it was not associated with glycemic control. Given the negative correlation between serum DPP4 and adiponectin levels, further investigations are warranted to elucidate the role of DPP4 on insulin sensitivity in T1DM children.