Mycoplasma genitalium urethritis in men
Mycoplasma genitalium urethritis in men
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DOI：
10.1016/j.ijantimicag.2004.02.006
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发表时间：
2004-09-01
影响因子：
10.8
通讯作者：
Deguchi, T
中科院分区：
文献类型：
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作者：
Ishihara, S;Yasuda, M;Deguchi, T
生殖支原体最初是从两名患有非淋菌性尿道炎（NGU）的男性中分离出来的，此后经尿道内接种表明它可在亚人类灵长类动物中引发尿道炎。在急性非淋菌性尿道炎患者中，尤其是在非衣原体性非淋菌性尿道炎患者中，检测到这种支原体的频率明显高于无尿道炎的受试者。生殖支原体阳性的非衣原体性非淋菌性尿道炎在所有非衣原体性非淋菌性尿道炎病例中的患病率为18% - 46%。此外，抗菌化疗后生殖支原体在尿道中的持续存在与非淋菌性尿道炎的持续或复发有关。迄今为止所报道的各种结果倾向于支持生殖支原体是非淋菌性尿道炎病原体这一观点。生殖支原体对四环素类、大环内酯类和一些新的氟喹诺酮类药物高度敏感，但关于生殖支原体阳性的非淋菌性尿道炎化疗的临床数据极其有限。由于尿道中生殖支原体在治疗后的存在与非淋菌性尿道炎的持续或复发之间可能存在关联，在治疗生殖支原体阳性的非淋菌性尿道炎患者时，从尿道中根除这种支原体至关重要。需要进一步的研究来确定生殖支原体阳性的非淋菌性尿道炎的最佳化疗方案。（C）2004爱思唯尔公司和国际化疗学会。版权所有。
Mycoplasma genitalium was first isolated from two men with non-gonococcal urethritis (NGU) and thereafter shown to produce urethritis in subhuman primates, inoculated intraurethrally. This mycoplasma has been detected significantly more often in patients with acute NGU, particularly in patients with non-chlamydial NGU, than in subjects without urethritis. The prevalence of M. genitalium-positive non-chlarnydial NGU ranges from 18 to 46% of all non-chlamydial NGU cases. In addition, the persistence of M. genitalium in the urethra after antimicrobial chemotherapy is associated with persistence or recurrence of NGU. The various results reported to date tend to support the proposition that M. genitalium is a pathogen of NGU. M. genitalium is highly susceptible to tetracyclines, macrolides, and some new fluoroquinol ones, but the clinical data on the chemotherapy in M. genitalium-positive NGU is extremely limited. Because of the possible association between the post-treatment presence of M. genitalium in the urethra and persistent or recurrent NGU, the eradication of this mycoplasma from the urethra is essential in the management of patients with M. genitalium-positive NGU. Further studies are required to establish the optimal chemotherapy for M. genitalium-positive NGU. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.