Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull.
Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull.
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DOI：
10.1038/s41598-017-03196-9
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发表时间：
2017-06-13
影响因子：
4.6
通讯作者：
Rasskin-Gutman D
中科院分区：
文献类型：
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作者：
Esteve-Altava B;Vallès-Català T;Guimerà R;Sales-Pardo M;Rasskin-Gutman D
颅缝闭合，颅骨过早融合，影响新生儿颅骨的正确发育，产生形态畸形。为了评估每个颅面关节过早关闭的易感性，我们使用颅骨网络模型来量化每个关节的连接可靠性（基于随机块模型和贝叶斯推理的指标）。我们表明，在出生时的93个人类颅骨关节中，与非综合征性颅缝闭闭相关的少数关节在统计上的可靠性评分明显低于其他关节。同样，在正常的颅骨产后发育过程中关闭的关节也比那些持续到成年的关节的可靠性评分低。这些结果表明，在正常发育和病理条件下，颅骨结构和特定关节之间存在关系。我们的研究结果表明，颅骨的拓扑结构可能是一种结构约束，在正常和病理发育中都容易导致一些关节关闭，也影响颅骨的长期进化。
Craniosynostosis, the premature fusion of cranial bones, affects the correct development of the skull producing morphological malformations in newborns. To assess the susceptibility of each craniofacial articulation to close prematurely, we used a network model of the skull to quantify the link reliability (an index based on stochastic block models and Bayesian inference) of each articulation. We show that, of the 93 human skull articulations at birth, the few articulations that are associated with non-syndromic craniosynostosis conditions have statistically significant lower reliability scores than the others. In a similar way, articulations that close during the normal postnatal development of the skull have also lower reliability scores than those articulations that persist through adult life. These results indicate a relationship between the architecture of the skull and the specific articulations that close during normal development as well as in pathological conditions. Our findings suggest that the topological arrangement of skull bones might act as a structural constraint, predisposing some articulations to closure, both in normal and pathological development, also affecting the long-term evolution of the skull.