THE LONG-TERM EFFECTS OF COPPER SURFACE-AREA ON MENSTRUAL BLOOD-LOSS AND IRON STATUS IN WOMEN FITTED WITH AN IUD
THE LONG-TERM EFFECTS OF COPPER SURFACE-AREA ON MENSTRUAL BLOOD-LOSS AND IRON STATUS IN WOMEN FITTED WITH AN IUD
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DOI：
10.1016/0010-7824(93)90136-u
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发表时间：
1993-11-01
期刊：
影响因子：
2.9
通讯作者：
RYBO, G
中科院分区：
文献类型：
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作者：
LARSSON, G;MILSOM, I;RYBO, G
在25名健康妇女中评价了铜表面积对月经失血量（MBL）和铁状态（血红蛋白、红细胞压积、红细胞计数和指数以及血清铁蛋白）的长期影响，这些妇女在放置宫内节育器后观察了3年。采用碱性高铁血红素法客观测定MBL。这些妇女（平均年龄37.2 ± 1.6岁，范围27-46岁）装有铜表面积为250 mm 2（MLCu-250，n = 13）或375 mm 2（MLCu-375，n = 12）的多负荷宫内节育器（IUD）。对于随后装配MLCu-250的女性，放置IUD前的MBL为55 +/- 8 ml，对于装配MLCu-375的女性，为59 +/- 9 ml。在放置IUD后的所有测量点均记录到MBL增加（MLCu-250/MLCu-375：3个月：55/49%; 6个月：58/49%; 12个月：64/41%; 24个月：55/49%; 36个月：47/39%，NS）。两组间放置IUD前铁状态参数无显著差异，放置IUD后这些参数也无显著变化。因此，我们的研究结果，铜表面积从250 mm 2增加到375 mm 2对MBL没有影响，证实了血液学结果。根据本研究的结果，发达国家的妇女显然可以耐受约45%的MBL增加而不发生贫血。铁储备不变，表明肠铁吸收的适当适应性增加。
The long-term effects of copper surface area on menstrual blood loss (MBL) and iron status (hemoglobin, hematocrit, red cell count and indices, and serum ferritin) were evaluated in 25 healthy women who were observed for a period of 3 years following insertion of an intrauterine device. MBL was determined objectively by the alkaline hematin method. The women (mean age 37.2 +/- 1.6 yr, range 27-46 yr) were fitted with a Multiload intrauterine device (IUD) with a copper surface area of either 250 mm2 (MLCu-250, n =,13) or 375 MM2 (MLCu-375, n = 12). MBL prior to IUD insertion was 55 +/- 8 ml for women subsequently fitted with a MLCu-250 and 59 +/- 9 ml for women fitted with a MLCu-375. An increase in MBL was recorded at all measurement points following IUD insertion (MLCu-250/MLCu-375: 3 months: 55/49%; 6 months: 58/49%; 12 months: 64/41%; 24 months: 55/49%; 36 months: 47/39%, NS). There were no significant differences in iron status parameters before IUD insertion between groups nor were there any significant changes recorded in any of these parameters after IUD insertion. Our findings that the increase in copper surface area from 250 mm2 to 375 MM2 had no effect on MBL were thus substantiated by the hematological findings. Based on the results of the present study, women from developed countries apparently tolerate an increased MBL of approximately 45% without developing anemia. Iron stores were unchanged indicating an adequate adaptive increase in intestinal iron absorption.