Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder
Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder
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DOI：
10.1001/archpsyc.58.6.545
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发表时间：
2001-06-01
影响因子：
--
通讯作者：
Everall, I
中科院分区：
文献类型：
--
作者：
Cotter, D;Mackay, D;Everall, I
背景：神经胶质细胞比皮质中的神经元数量更多，对神经元功能至关重要。有证据表明精神分裂症的神经元大小减少，并有证据表明情绪障碍的神经胶质细胞密度减少。在这项研究中，我们同时评估了精神分裂症、重度抑郁症和双相情感障碍的前扣带皮层中的胶质细胞密度和神经元密度和大小。方法：我们检查了 4 组 15 名受试者的 69 个后现代脑标本中胼胝体上前扣带皮层 24b 区域的组织，如下：重度抑郁症、 精神分裂症、双向情感障碍和正常对照。使用成核器和光学解剖器检查所有受试者的胶质细胞密度和神经元大小和密度。结果：与对照组相比，重度抑郁症第 6 层的胶质细胞密度 (22%) (P=.004) 和神经元大小 (23%) (P=.01) 减少。有一些证据表明，在调整多层比较之前，精神分裂症患者的第 6 层神经胶质密度 (20%) (P=.02) 与对照组相比有所降低，但神经元大小没有显着变化。没有证据表明双相情感障碍患者的神经胶质密度或神经元大小与对照组相比存在差异。所有组中的神经元密度与对照组相似。结论：这些发现表明，重度抑郁症患者的额叶皮层神经胶质细胞密度和神经元大小均减少。
Background: Glial cells are more numerous than neurons in the cortex and are crucial to neuronal function. There is evidence for reduced neuronal size in schizophrenia, with suggestive evidence for reduced glial cell density in mood disorders. In this investigation, we have simultaneously assessed glial cell density and neuronal density and size in the anterior cingulate cortex in schizophrenia, major depressive disorder, and bipolar disorder.Methods: We examined tissue from area 24b of the supracallosal anterior cingulate cortex in 69 postmodern brain specimens from 4 groups of 15 subjects, as follows: major depressive disorder, schizophrenia, bipolar disorder, and normal controls. Glial cell density and neuronal size and density were examined in all subjects using the nucleator and the optical disector.Results: Glial cell density (22%) (P=.004) and neuronal size (23%) (P=.01) were reduced in layer 6 in major depressive disorder compared with controls. There was some evidence for reduced glial density in layer 6 (20%) (P=.02) in schizophrenia compared with controls, before adjusting for multiple layerwise comparisons, but there were no significant changes in neuronal size. There was no evidence for differences in glial density or neuronal size in bipolar disorder compared with controls. Neuronal density was similar in all groups to that found in controls.Conclusion: These findings suggest that there is reduced frontal cortical glial cell density and neuronal size in major depressive disorder.