Meiotic transverse filament proteins: essential for crossing over
Meiotic transverse filament proteins: essential for crossing over
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DOI：
10.1007/s11248-005-8925-y
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发表时间：
2005-10-01
影响因子：
3
通讯作者：
Heyting, C
中科院分区：
文献类型：
--
作者：
Heyting, C
减数分裂是一组特殊的两次核分裂，即减数分裂 I 和 II，二倍体细胞通过减数分裂产生四个单倍体子代。减数分裂前 DNA 复制后，同源染色体配对并重组，然后在减数分裂 I 时分离。随后，在减数分裂 II 时，每条染色体的姐妹染色单体分离。在几乎所有真核生物中，减数分裂染色体配对最终形成梯状超分子蛋白质结构，即联会复合体（SC）（Page 和 Hawley，2004）。梯子的横档称为横向横档。哀叹（TF）。已在有限数量的生物体中鉴定出编码 TF 蛋白的基因，并通过突变分析研究了它们的功能。尽管TF蛋白显示出很少的氨基酸序列保守性，但它们的结构和功能在很大程度上是保守的。在所有分析的物种中，减数分裂相互重组（交叉）都需要 TF 蛋白。
Meiosis is a specialized set of two nuclear divisions, meiosis I and II, by which a diploid cell produces four haploid daughters. After premeiotic DNA replication, homologous chromosomes pair and recombine, and then disjoin at meiosis I. Subsequently, at meiosis II, the sister chromatids of each chromosome segregate. In nearly all eukaryotes, meiotic chromosome pairing culminates in the formation of a ladderlike supramolecular protein structure, the synaptonemal complex (SC) ( Page and Hawley, 2004). The rungs of the ladder are known as transverse. laments (TFs). Genes encoding TF proteins have been identified in a limited number of organisms, and their function has been studied by mutational analysis. Although TF proteins show little amino acid sequence conservation, their structure and function are largely conserved. In all analyzed species, TF proteins are required for meiotic reciprocal recombination (crossing over).