Quantitative aspects of the multiplication of influenza A virus in the mouse lung; relation between the degree of viral multiplication and the extent of pneumonia.
Quantitative aspects of the multiplication of influenza A virus in the mouse lung; relation between the degree of viral multiplication and the extent of pneumonia.
复制标题
DOI：
10.1084/jem.95.2.135
复制
发表时间：
1952-02
影响因子：
15.3
通讯作者：
HORSFALL, F L Jr
中科院分区：
文献类型：
--
作者：
GINSBERG, H S;HORSFALL, F L Jr
甲型流感病毒PR8株在感染小鼠肺中的数量以相对恒定的速率增加。当接种超过25ms .50剂量的病毒时，增殖率似乎与引入的病毒量无关；价值每天增长1100倍。PR8感染小鼠肺部引起的肺病变增加率似乎也相对恒定，与病毒接种量无关；每天增加8.5倍。pr8 -小鼠肺系统的基本变量似乎与先前(4)在小鼠肺炎病毒（PVM）的类似定量研究中得出的功能令人满意地相等。提出了支持PR8和PVM在小鼠肺中增殖过程不同的假设的证据。
Influenza A virus, PR8 strain, increases in amount in the infected mouse lung at a relatively constant rate. When more than 25 M.S.50 doses of virus is inoculated, the rate of multiplication appears to be independent of the amount of virus introduced; has a value of 1,100-fold increase per day. The rate of increase in the pulmonary lesions induced by infection of the mouse lung with PR8 also appears to be relatively constant and independent of the amount of virus inoculated; has a value of 8.5-fold increase per day. The essential variables in the PR8-mouse lung system appear to be equated satisfactorily by functions which were derived previously (4) during a similar quantitative investigation on pneumonia virus of mice (PVM). Evidence in support of the hypothesis that the processes of multiplication of PR8 and PVM are different in the mouse lung is presented.