Poly(ethoxytriethyleneglycol acrylate) cryogels as novel sustained drug release systems for oral application
Poly(ethoxytriethyleneglycol acrylate) cryogels as novel sustained drug release systems for oral application
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DOI：
10.1016/j.polymer.2011.01.049
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发表时间：
2011-03
期刊：
影响因子：
4.6
通讯作者：
B. Kostova;D. Momekova;P. Petrov;G. Momekov;Natalia Toncheva-Moncheva;C. Tsvetanov;N. Lambov
中科院分区：
文献类型：
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作者：
B. Kostova;D. Momekova;P. Petrov;G. Momekov;Natalia Toncheva-Moncheva;C. Tsvetanov;N. Lambov
采用紫外光照射技术合成了聚乙氧基三甘醇丙烯酸酯（PETEGA）温敏性冻凝胶，并将其作为亲水性药物盐酸维拉帕米的控释基质。PETEGA冻凝胶是无毒材料，由于其大孔结构，在温度约为100 ℃时呈现可逆的超快速体积相变。31 °C。基于PETEGA冻凝胶的载体具有超过8 h的盐酸维拉帕米缓释，这归因于聚合物网络在生理温度下的疏水状态和药物固定化方法。PETEGA冻凝胶的药物释放特性与另一种冻凝胶系统进行了比较，基于聚丙烯酰胺（PAAm），聚（N-异丙基丙烯酰胺）（PNIPAAm）和聚（2-羟乙基甲基丙烯酸酯）（PHEMA），通过相同的方法获得。
Novel temperature sensitive cryogels of poly(ethoxytriethyleneglycol acrylate) (PETEGA), with in situ entrapped active substance, are synthesized employing the UV irradiation technique and tested as matrix for controlled release of the hydrophilic drug verapamil hydrochloride. PETEGA cryogels are non-toxic materials and, due to the macroporous structure, exhibit a reversible, ultra-rapid volume phase transition at temperature ca. 31 °C. Carriers based on PETEGA cryogels possess sustained release of verapamil hydrochloride over a period of more than 8 h, which is attributed to the hydrophobic state of the polymer network at physiological temperature and the method of drug immobilization. Drug release characteristics of PETEGA cryogels are compared with another cryogel systems, based on polyacrylamide (PAAm), poly(N-isopropylacrylamide) (PNIPAAm) and poly(2-hydroxyethyl methacrylate) (PHEMA), obtained via the same method.