Escherichia coli cells bearing a ribosomal ambiguity mutation in rpsD have a mutator phenotype that correlates with increased mistranslation
Escherichia coli cells bearing a ribosomal ambiguity mutation in rpsD have a mutator phenotype that correlates with increased mistranslation
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DOI：
10.1128/jb.185.16.5015-5018.2003
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发表时间：
2003-08-01
影响因子：
3.2
通讯作者：
Humayun, MZ
中科院分区：
文献类型：
--
作者：
Balashov, S;Humayun, MZ
在rpsD（编码30S核糖体蛋白S4）中携带某些突变的大肠杆菌细胞显示核糖体模糊（Ram）表型，其特征在于增加的翻译错误率。在这里，我们表明，自发突变增加Ram细胞轴承rpsD14等位基因，这表明最近描述的翻译应力诱导的诱变途径在Ram细胞中被激活。
Escherichia coli cells bearing certain mutations in rpsD (coding for the 30S ribosomal protein S4) show a ribosomal ambiguity (Ram) phenotype characterized by increased translational error rates. Here we show that spontaneous mutagenesis increases in Ram cells bearing the rpsD14 allele, suggesting that the recently described translational stress-induced mutagenesis pathway is activated in Ram cells.