Liver cirrhosis
Liver cirrhosis
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DOI：
10.1016/s0140-6736(14)60121-5
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发表时间：
2014-05-17
期刊：
影响因子：
168.9
通讯作者：
Burroughs, Andrew K.
中科院分区：
文献类型：
--
作者：
Tsochatzis, Emmanuel A.;Bosch, Jaime;Burroughs, Andrew K.
肝硬化在较发达国家是发病率和死亡率不断增加的原因，是全世界第14位最常见的死亡原因，但在中欧是第四位。越来越多地，肝硬化已被视为不是一个单一的疾病实体，但可以细分为不同的临床预后阶段，1年死亡率范围从1%到57%取决于阶段。我们回顾了目前对肝硬化作为一个动态过程的认识，并概述了目前肝硬化并发症的预防和治疗的治疗方案，在临床分期的亚分类的基础上。肝硬化患者管理的新概念应该是预防和早期干预，以稳定疾病进展，避免或延迟临床失代偿和肝移植的需要。世纪的挑战是尽可能多地防止肝硬化患者需要肝移植。
Cirrhosis is an increasing cause of morbidity and mortality in more developed countries, being the 14th most common cause of death worldwide but fourth in central Europe. Increasingly, cirrhosis has been seen to be not a single disease entity, but one that can be subclassified into distinct clinical prognostic stages, with 1-year mortality ranging from 1% to 57% depending on the stage. We review the current understanding of cirrhosis as a dynamic process and outline current therapeutic options for prevention and treatment of complications of cirrhosis, on the basis of the subclassification in clinical stages. The new concept in management of patients with cirrhosis should be prevention and early intervention to stabilise disease progression and to avoid or delay clinical decompensation and the need for liver transplantation. The challenge in the 21st century is to prevent the need for liver transplantation in as many patients with cirrhosis as possible.