Modular Design of Supramolecular Ionic Peptides with Cell‐Selective Membrane Activity
Modular Design of Supramolecular Ionic Peptides with Cell‐Selective Membrane Activity
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DOI：
10.1002/cbic.202100323
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发表时间：
2021-09
期刊：
影响因子：
3.2
通讯作者：
Su Yang;Yan Chang;Shan Hazoor;C. Brautigam;F. Foss;Zui Pan;He Dong
中科院分区：
文献类型：
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作者：
Su Yang;Yan Chang;Shan Hazoor;C. Brautigam;F. Foss;Zui Pan;He Dong
合理设计具有细胞选择性膜活性的材料是发展靶向分子成像和治疗的有效策略。在这里，我们报道了一类新的阳离子多结构域肽(MDP)，它可以通过酶介导的分子转化和超分子组装形成纳米纤维，其中阳离子簇呈现在刚性的β-Sheet骨架上。这种由细胞过度表达特定酶引起的结构转换，导致了MDP膜扰动电位的变化，从而提高了细胞摄取和药物传递的效率。我们设想，基于模块化设计的MDP的定向自组装是一种非常有前途的方法，可以生成具有新兴膜活性的动态超分子纳米材料，用于一系列疾病靶向分子成像和治疗应用。
The rational design of materials with cell‐selective membrane activity is an effective strategy for the development of targeted molecular imaging and therapy. Here we report a new class of cationic multidomain peptides (MDPs) that can undergo enzyme‐mediated molecular transformation followed by supramolecular assembly to form nanofibers in which cationic clusters are presented on a rigid β‐sheet backbone. This structural transformation, which is induced by cells overexpressing the specific enzymes, led to a shift in the membrane perturbation potential of the MDPs, and consequently enhanced cell uptake and drug delivery efficacy. We envision the directed self‐assembly based on modularly designed MDPs as a highly promising approach to generate dynamic supramolecular nanomaterials with emerging membrane activity for a range of disease targeted molecular imaging and therapy applications.