Basic concepts in the study of diseases with complex genetics
Basic concepts in the study of diseases with complex genetics
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DOI：
10.1016/s0006-3223(98)00316-3
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发表时间：
1999-03-01
影响因子：
10.6
通讯作者：
Burmeister, M
中科院分区：
文献类型：
--
作者：
Burmeister, M
大多数疾病都是家族遗传的——几乎所有的精神疾病都是如此。双胞胎和收养研究表明，大多数精神疾病都有遗传成分，但已知的遗传因素很少，正如大多数具有复杂遗传起源的疾病一样。在这里，我以精神病学遗传学为例，回顾非遗传学家在研究复杂遗传疾病时使用的一些基本术语和概念。这篇综述旨在帮助理解和批判性评价文献中关于精神疾病遗传学的报道。生物精神病学1999；[45]中华医学会精神病学分会。
Most diseases run in families-this is also true of virtually all psychiatric disorders. Twin and adoption studies have shown that most psychiatric disorders have a genetic component, yet very few genetic factors are known, as is true for most disorders with a complex genetic origin. Here I review for nongeneticists, some of the basic terminology and concepts used when studying complex genetic diseases, with examples from psychiatric genetics. This review is intended to help in the understanding and critical evaluation of reports on genetics of psychiatric illnesses in the literature. Biol Psychiatry 1999;45: 522-532 (C) 1999 Society of Biological Psychiatry.